Correlation between plasma, synovial fluid and articular cartilage Interleukin-18 with radiographic severity in 33 patients with osteoarthritis of the knee

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• 作者：Youhua Wang (1)
  Dawei Xu (2)
  Long Long (3)
  Xiaolong Deng (3)
  Ran Tao (3)
  Guicheng Huang (1)
  
• 关键词：Interleukin ; 18 (IL ; 18) ; Osteoarthritis (OA) ; Plasma ; Synovial fluid ; Cartilage
• 刊名：Clinical and Experimental Medicine
• 出版年：2014
• 出版时间：August 2014
• 年：2014
• 卷：14
• 期：3
• 页码：297-304
• 全文大小：2,644 KB
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• 作者单位：Youhua Wang (1)
  Dawei Xu (2)
  Long Long (3)
  Xiaolong Deng (3)
  Ran Tao (3)
  Guicheng Huang (1)
  
  1. Nanjing University of Chinese Medicine, Nanjing, 210046, People’s Republic of China
  2. Department of Orthopaedics, The Second Affiliated Hospital of Nantong University, Nantong, 226001, People’s Republic of China
  3. Department of Orthopaedics, Affiliated Hospital of Nantong University, Nantong, 226001, People’s Republic of China
  
• ISSN：1591-9528

文摘

Osteoarthritis (OA) is a complex disease characterized by cartilage degeneration, secondary synovial membrane inflammation and subchondral bone changes. In recent years, many studies have confirmed that interleukin-18 (IL-18) is involved in the inflammatory process of inflammatory joint diseases. In the present study, we investigated IL-18 levels in plasma, synovial fluid and articular cartilage of patients with primary knee OA (n?=?33) to analyze their relationship with radiographic severity. Compared to healthy controls (n?=?15), OA patients had higher plasma and synovial fluid IL-18 concentrations (45.8?±?22.1 vs. 23.7?±?13.6?pg/ml, P?P?P?r?=?0.663, P?r?=?0.56, P?=?0.001 and r?=?0.884, P?r?=?0.632, P?r?=?0.489, P?=?0.004 and r?=?0.620, P?