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作者单位:Sebastian Will (20) Peter F. Stadler (20) (21) (22) (23) (24) (25) (26)
20. Dept. Computer Science, and Interdisciplinary Center for Bioinformatics, Univ. Leipzig, H盲rtelstr. 16-18, Leipzig, Germany 21. MPI Mathematics in the Sciences, Inselstr. 22, Leipzig, Germany 22. FHI Cell Therapy and Immunology, Perlickstr. 1, Leipzig, Germany 23. Dept. Theoretical Chemistry, Univ. Vienna, W盲hringerstr. 17, Wien, Austria 24. Bioinformatics and Computational Biology research group, University of Vienna, A-1090 W盲hringerstra脽e 17, Vienna, Austria 25. RTH, Univ. Copenhagen, Gr酶nneg氓rdsvej 3, Frederiksberg C, Denmark 26. Santa Fe Institute, 1399 Hyde Park Rd., Santa Fe, USA
ISSN:1611-3349
文摘
Circularized RNAs have received considerable attention is the last few years following the discovery that they are not only a rather common phenomenon in the transcriptomes of Eukarya and Archaea but also may have key regulatory functions. This calls for the adaptation of basic tools of sequence analysis to accommodate cyclic sequences. Here we discuss a common formal framework for linear and circular alignments as partitions that preserve (cyclic) order. We focus on the similarities and differences and describe a prototypical ILP formulation.