Current evidences on the XPG Asp1104His polymorphism and melanoma susceptibility: a meta-analysis based on case–control studies

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• 作者：Yuanzhi Xu ; Guangjun Jiao ; Li Wei ; Ning Wang ; Yajun Xue…
• 关键词：XPG Asp1104His ; Polymorphism ; Melanoma ; Meta ; analysis
• 刊名：Molecular Genetics and Genomics
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：290
• 期：1
• 页码：273-279
• 全文大小：919 KB
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• 作者单位：Yuanzhi Xu (1)
  Guangjun Jiao (2)
  Li Wei (3) (4)
  Ning Wang (3)
  Yajun Xue (1)
  Jin Lan (1)
  Yajie Wang (3)
  Chuan Liu (3)
  Meiqing Lou (1)
  
  1. Department of Neurosurgery, Shanghai First People’s Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai, 200080, China
  2. Musculoskeletal Tumor Center, People’s Hospital, Peking University, Beijing, China
  3. Department of Oncology, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200433, China
  4. Department of Oncology, The 401 Hospital of PLA, Qingdao, Shandong, China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Cell Biology
  Biochemistry
  Microbial Genetics and Genomics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1617-4623

文摘

Previous studies evaluating the association between the XPG Asp1104His polymorphism and melanoma susceptibility remained controversial. To draw a more precise estimation of the relationship, a total of eight published case–control studies containing 5,212 cases and 7,045 controls were included for meta-analysis. Overall, a significant association was found between the XPG Asp1104His polymorphism and melanoma susceptibility for the dominant model (OR?=?2.42, 95?% CI?=?2.26-.60). In subgroup analysis by source of control, there was an obvious association was found among Population-based subgroup for the dominant model CC+GC vs GG (OR 2.51, 95?% CI 2.28-.77), among the Hospital-based subgroup, an obvious association was also found for the dominant model CC+GC vs GG (OR 2.34, 95?% CI 2.12-.58). This meta-analysis suggested that the XPG Asp1104His polymorphism was a risk factor for melanoma susceptibility.