Effect of alkali on konjac glucomannan film and its application on wound healing

详细信息    查看全文

• 作者：Yi-Cheng Huang ; Chi-Yu Yang ; Hao-Wen Chu ; Wen-Ching Wu ; Jenn-Shou Tsai
• 关键词：Alkali ; Konjac glucomannan ; Film ; Wound dressing
• 刊名：Cellulose
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：22
• 期：1
• 页码：737-747
• 全文大小：3,572 KB
• 参考文献：1. Balakrishnan B, Mohanty M, Umashankar PR, Jayakrishnan A (2005) Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin. Biomaterials 26(32):6335-342. doi:10.1016/j.biomaterials.2005.04.012 CrossRef
  2. Benbow M (2010) Managing wound pain: is there an ‘ideal dressing- Br J Nurs 19(20):1273-274 CrossRef
  3. Brandi C, Grimaldi L, Nisi G, Brafa A, Campa A, Calabro M, Campana M, D’Aniello C (2010) The role of carbon dioxide therapy in the treatment of chronic wounds. In Vivo 24(2):223-26
  4. Cheng LH, Karim AA, Norziah MH, Seow CC (2002) Modification of the microstructural and physical properties of konjac glucomannan-based films by alkali and sodium carboxymethylcellulose. Food Res Int 35(9):829-36 CrossRef
  5. Coskun G, Karaca E, Ozyurtlu M, Ozbek S, Yermezler A, Cavusoglu I (2014) Histological evaluation of wound healing performance of electrospun poly(vinyl alcohol)/sodium alginate as wound dressing in vivo. Biomed Mater Eng 24(2):1527-536. doi:10.3233/BME-130956
  6. Dressler DP, Barbee WK, Sprenger R (1980) The effect of Hydron burn wound dressing on burned rat and rabbit ear wound healing. J Trauma 20(12):1024-028 CrossRef
  7. Fan L, Cheng C, Qiao Y, Li F, Li W, Wu H, Ren B (2013) GNPs-CS/KGM as hemostatic first aid wound dressing with antibiotic effect: in vitro and in vivo study. PLoS One 8(7):e66890. doi:10.1371/journal.pone.0066890 CrossRef
  8. Gethin G (2004) Is there enough clinical evidence to use honey to manage wounds? J Wound Care 13(7):275-78 CrossRef
  9. Gethin GT, Cowman S, Conroy RM (2008) The impact of Manuka honey dressings on the surface pH of chronic wounds. Int Wound J 5(2):185-94. doi:10.1111/j.1742-481X.2007.00424.x CrossRef
  10. Greener B, Hughes AA, Bannister NP, Douglass J (2005) Proteases and pH in chronic wounds. J Wound Care 14(2):59-1 CrossRef
  11. Harkins AL, Duri S, Kloth LC, Tran CD (2014) Chitosan–cellulose composite for wound dressing material. Part 2. Antimicrobial activity, blood absorption ability, and biocompatibility. J Biomed Mater Res B Appl Biomater. doi:10.1002/jbm.b.33103
  12. Herranz B, Tovar CA, Solo-de-Zaldivar B, Borderias AJ (2013) Influence of alkali and temperature on glucomannan gels at high concentration. LWT Food Sci Technol 51:500-06 CrossRef
  13. Huang L, Takahashi R, Kobayashi S, Kawase T, Nishinari K (2002) Gelation behavior of native and acetylated konjac glucomannan. Biomacromolecules 3(6):1296-303 CrossRef
  14. Huang YC, Hsu SH, Kuo WC, Chang-Chien CL, Cheng H, Huang YY (2011) Effects of laminin-coated carbon nanotube/chitosan fibers on guided neurite growth. J Biomed Mater Res A 99(1):86-3. doi:10.1002/jbm.a.33164 CrossRef
  15. Jin W, Mei T, Wang Y, Xu W, Li J, Zhou B, Li B (2014) Synergistic degradation of konjac glucomannan by alkaline and thermal method. Carbohydr Polym 99:270-77. doi:10.1016/j.carbpol.2013.08.029 CrossRef
  16. Kim HJ, Choi EY, Oh JS, Lee HC, Park SS, Cho CS (2000) Possibility of wound dressing using poly(l -leucine)/poly(ethylene glycol)/poly(l -leucine) triblock copolymer. Biomate
• 作者单位：Yi-Cheng Huang (1)
  Chi-Yu Yang (2)
  Hao-Wen Chu (1)
  Wen-Ching Wu (1)
  Jenn-Shou Tsai (1)
  
  1. Department of Food Science, College of Life Science, National Taiwan Ocean University, No. 2, Pei-Ning Road, Keelung, 20224, Taiwan
  2. Animal Technology Laboratories, Agriculture Technology Research Institute, Zhunan, Miaoli County, 35053, Taiwan
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Bioorganic Chemistry
  Physical Chemistry
  Organic Chemistry
  Polymer Sciences
  
• 出版者：Springer Netherlands
• ISSN：1572-882X

文摘

Konjac glucomannan (KGM) is widely used in the food industry because of its biocompatibility, nontoxicity, and favorable film-forming ability. However, KGM has been seldom applied to biomaterials for tissue regeneration. In this paper, we investigate the effects of Ca(OH)2 on KGM film and evaluate its potency as a wound dressing. We successfully prepared Ca(OH)2-treated KGM film. High Ca(OH)2 concentrations created rough film surfaces. These rough surfaces resulted from the deposition of nanosized or microsized CaCO3(s). Compared with commercially available 3M hydrocolloid dressings, dressings with KGM exhibited a more favorable degree of swelling and water vapor transmission rate. The film with a Ca(OH)2/KGM weight ratio of 2.5?% exhibited the optimal tensile strength and elongation. The results of an in vitro MTT [3-4,5‐dimethylthiazol-‐yl)-,5‐diphenyltetrazolium bromide] cell viability assay revealed the favorable biocompatibility of KGM films with L929 cells. For antibacterial evaluation, tetracycline-loaded KGM film exhibited strong inhibitory effects against Staphylococcus aureus with a 2.5-cm inhibition zone. In vivo animal studies have indicated that KGM films effectively promote the contractility of wounds, especially at the early healing stage. Histological examinations have also demonstrated that using KGM films to treat wounds enables considerably advanced granulation tissue and epithelial coverage to develop by the 7th and 14th?days of treatment. In summary, Ca(OH)2-treated KGM film could be considered as a promising, novel, biocompatible wound dressing.