Glycine hydroxamate inhibits tyrosinase activity and melanin contents through downregulating cAMP/PKA signaling pathways

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• 作者：Yin-Shiou Lin ; Wen-Chung Wu ; Shyr-Yi Lin ; Wen-Chi Hou
• 关键词：Glycine hydroxamate ; Hypopigmentation ; Isobutylmethylxanthine ; Melanin ; microphthalmia ; associated transcription factor ; Protein kinase A ; Tyrosinase
• 刊名：Amino Acids
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：47
• 期：3
• 页码：617-625
• 全文大小：704 KB
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• 作者单位：Yin-Shiou Lin (1)
  Wen-Chung Wu (1)
  Shyr-Yi Lin (2) (3)
  Wen-Chi Hou (4)
  
  1. Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan
  2. Department of Primary Care Medicine, Taipei Medical University Hospital, Taipei, Taiwan
  3. Department of General Medicine, School of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, Taiwan
  4. Graduate Institute of Pharmacognosy, Taipei Medical University and Traditional Herbal Medicine Research Center, Taipei Medical University Hospital, 250 Wu-Hsing Street, Taipei, Taiwan
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Analytical Chemistry
  Biochemical Engineering
  Life Sciences
  Proteomics
  Neurobiology
  
• 出版者：Springer Wien
• ISSN：1438-2199

文摘

Among the eight amino acid hydroxamates tested, Glycine hydroxamate (GH) was the best inhibitor of mushroom tyrosinase (TYR). With l-tyrosine as substrate, the GH inhibition of the monophenolase activity of the mushroom TYR was noncompetitive. GH decreased not only TYR protein expression, but also melanin content, tyrosinase-related protein (TRP)-1, TRP-2, and microphthalmia-associated transcription factor (MITF) expression in B16F10 melanoma cells while in the presence of α-melanocyte-stimulating hormone (α-MSH). GH also significantly decreased the isobutylmethylxanthine (IBMX)-induced increase in melanin content, which was not prevented by the ERK inhibitor PD98059. These results suggest GH has the potential for use in cosmetic hypopigmentation.