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Evaluation of 153Sm/177Lu-EDTMP mixture in wild-type rodents as a novel combined palliative treatment of bone pain agent
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  • 作者：Hassan Ranjbar ; Ali Bahrami-Samani…
  • 关键词：153Sm/177Lu ; EDTMP ; Combined radiopharmaceutical ; Biodistribution ; Pain palliation ; Bone metastases
  • 刊名：Journal of Radioanalytical and Nuclear Chemistry
  • 出版年：2015
  • 出版时间：January 2015
  • 年：2015
  • 卷：303
  • 期：1
  • 页码：71-79
  • 全文大小：1,205 KB
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文摘
In this work, the cocktail complex 153Sm/177Lu-EDTMP was prepared in high radiochemical purity (more than 99?%) using in house synthesized EDTMP ligand for obtaining a possible synergistic wide range palliative agent. The mixture was administered to wild-type rats and biodistribution data collected after 2?h to 7?days showed at least 70?% accumulation of the radioactivity in the bone tissues. Scintigraphic images were taken from wild-type rats injected with 153Sm/177Lu-EDTMP after 24?h and the biodistribution was shown to be consistent with post-mortem data. A comparative accumulation study was performed for vital organs up to 7?days. 153Sm/177Lu-EDTMP seemed a promising agent for bone pain palliation therapy in skeletal metastases in humans as a novel combined radiopharmaceutical.

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