Prevention of postoperative tendon adhesion by biodegradable electrospun membrane of poly(lactide-co-glycolide)

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• 作者：Zhi-ming Song ; Bo Shi ; Jian-xun Ding …
• 关键词：Anti ; adhesion ; Achilles tendon repair ; Biodegradability ; Electrospun membrane ; Poly(lactide ; co ; glycolide)
• 刊名：Chinese Journal of Polymer Science
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：33
• 期：4
• 页码：587-596
• 全文大小：1,727 KB
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• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Condensed Matter Physics
  Industrial Chemistry and Chemical Engineering
  Polymer Sciences
  Characterization and Evaluation of Materials
  
• 出版者：Chinese Chemical Society and Institute of Chemistry, CAS, co-published with Springer
• ISSN：1439-6203

文摘

An electrospun poly(lactide-co-glycolide) (PLGA) membrane was prepared and used to perform the anti-adhesion of Achilles tendon. Throughout the experiments, the membrane showed an appropriate degradation rate, and the pH values of degradation media were maintained at around 7.4. Simultaneously, the excellent biocompatibility of the membrane in vitro and in vivo was confirmed by live/dead and histopathological analyses. Meanwhile, the membrane can reduce tendon adhesion significantly and promote functional recovery effectively. The encouraging results were further demonstrated by hematoxylin and eosin (H&E), and Masson’s trichrome stainings, and type I collagen immunohistochemical analysis. It was concluded that the model treated with the electrospun PLGA membrane was significantly better with respect to the adhesion prevention and tissue repair than that without treatment. Considering the results of degradation and adhesion prevention efficacy, the electrospun PLGA membrane would be a great candidate for the prevention of postoperative tendon adhesion.