Effects of a short-term reduction in brain serotonin synthesis on the availability of the soluble leptin receptor in healthy women

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• 作者：F. D. Zepf (1) (2) (6)
  V. L. S. Dingerkus (1) (2)
  K. Helmbold (1) (2)
  S. Bubenzer-Busch (1) (2)
  C. S. Biskup (1) (2)
  B. Herpertz-Dahlmann (1) (2)
  M. Schaab (3)
  J. Kratzsch (3)
  A. Eisert (4)
  L. Rink (5)
  U. Hagenah (1)
  T. J. Gaber (1) (2)
  
  1. Clinic for Child and Adolescent Psychiatry ; Psychosomatics and Psychotherapy ; RWTH Aachen University ; Aachen ; Germany
  2. JARA Translational Brain Medicine ; Aachen and J眉lich ; Germany
  6. Institute for Neuroscience and Medicine ; J眉lich Research Center ; J眉lich ; Germany
  3. Institute of Laboratory Medicine ; Clinical Chemistry and Molecular Diagnostics ; University of Leipzig ; Leipzig ; Germany
  4. Department of Pharmacy ; RWTH Aachen University Hospital ; Aachen ; Germany
  5. Department of Immunology ; RWTH Aachen University Hospital ; Aachen ; Germany
  
• 关键词：Serotonin ; Soluble leptin receptor ; Eating disorders ; Leptin
• 刊名：Journal of Neural Transmission
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：122
• 期：3
• 页码：343-348
• 全文大小：173 KB
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Neurology
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Wien
• ISSN：1435-1463

文摘

Serotonin (5-HT) and the hormone leptin have been linked to the underlying neurobiology of appetite regulation with evidence coming from animal and cellular research, but direct evidence linking these two pathways in humans is lacking. We examined the effects of reduced brain 5-HT synthesis due to acute tryptophan depletion (ATD) on levels of soluble leptin receptor (sOb-R), the main high-affinity leptin binding protein, in healthy adults using an exploratory approach. Women, but not men, showed reduced sOb-R concentrations after ATD administration. With females showing reduced baseline levels of central 5-HT synthesis compared to males diminished brain 5-HT synthesis affected the leptin axis through the sOb-R in females, thereby potentially influencing their vulnerability to dysfunctional appetite regulation and co-morbid mood symptoms.