Red blood cell distribution width predicts outcome of cryoballoon-based atrial fibrillation ablation

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• 作者：Kadri Murat Gurses ; Muhammed Ulvi Yalcin…
• 关键词：Red blood cell distribution width ; Atrial fibrillation ; Cryoablation ; Recurrence
• 刊名：Journal of Interventional Cardiac Electrophysiology
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：42
• 期：1
• 页码：51-58
• 全文大小：293 KB
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Cardiology
  
• 出版者：Springer Netherlands
• ISSN：1572-8595

文摘

Purpose Elevated red blood cell distribution width (RDW) has been associated with atrial fibrillation (AF) in cross-sectional and prospective studies. In this study, we aim to evaluate the relation of preablation RDW levels to late AF recurrence following cryoablation. Methods A total of 299 patients with symptomatic paroxysmal or persistent AF despite ? antiarrhythmic drug(s) who were scheduled for cryoballoon-based AF ablation were enrolled in this prospective study. Results A total of 299 patients (55.40?±-0.60years, 49.20?% male) were involved and followed up at a median time of 24 (6-4) months. Patients with late AF recurrence had higher RDW levels (14.30?±-.93 vs. 13.52?±-.93?%, p--.001). Multivariate Cox proportional hazard regression analysis showed that RDW level was an independent predictor for late AF recurrence (HR 1.88, 95?% CI 1.41-.50, p--.001) along with left atrial (LA) diameter (HR 3.09, 95?% CI 1.81-.27, p--.001), duration of AF (HR 1.04, 95?% CI 1.01-.07, p--.02), and early AF recurrence (HR 6.39, 95?% CI 3.41-1.97, p--.001). A cut-off level of 13.75?% for RDW predicted late AF recurrence following cryoballoon-based pulmonary vein isolation (PVI) with a sensitivity and specificity of 78.00 and 70.00?%, respectively. Conclusion These findings suggest that elevated RDW may be a predictor of late recurrence following cryoballoon-based AF ablation. Further studies are needed to establish its exact pathophysiologic and prognostic roles.