Overexpression of GOLPH3 protein is associated with worse prognosis in patients with epithelial ovarian cancer

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• 作者：Yingchun Ma ; Xiuxia Wang ; Yuanhong Wu ; Binghui Sun ; Hongtao Lv…
• 关键词：Epithelial ovarian cancer ; Golgi phosphoprotein 3 ; Prognosis
• 刊名：Tumor Biology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：35
• 期：12
• 页码：11845-11849
• 全文大小：201 KB
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• 作者单位：Yingchun Ma (1) (2)
  Xiuxia Wang (2)
  Yuanhong Wu (3)
  Binghui Sun (1)
  Hongtao Lv (1)
  Fengnian Rong (1)
  Xiaoxia Zheng (4)
  
  1. Department of Gynecology and Obstetrics, Shandong Qianfoshan Hospital, Shandong University, Jinan, Shandong, 250014, People’s Republic of China
  2. Department of Obstetrics and Gynecology, Liaocheng People’s Hospital, Liaocheng, Shandong, 252000, People’s Republic of China
  3. Department of Gynecology and Obstetrics, Jinan Shizhong People’s Hospital, Shandong, 250002, People’s Republic of China
  4. Department of Gynecology and Obstetrics, Jinan Maternity and Child Healthcare Hospital, Shandong, 250001, People’s Republic of China
  
• 刊物主题：Cancer Research;
• 出版者：Springer Netherlands
• ISSN：1423-0380

文摘

Golgi phosphoprotein 3 (GOLPH3) has important roles in the pathogenesis of cancer, and overexpression of GOLPH3 has been found in several kinds of cancers. However, the relationship between GOLPH3 overexpression and prognosis in patients with epithelial ovarian cancer remains unknown. This study aimed to investigate the relationship between GOLPH3 overexpression and overall survival in patients with epithelial ovarian cancer. The expression of GOLPH3 protein in tumor tissue was evaluated using immunohistochemistry. Seventy-five patients with epithelial ovarian cancer with the data of GOLPH3 expression and follow-up were included. GOLPH3 overexpression was significantly associated with advanced stage, histology, high grade, and lymph node metastases (P--.05). Kaplan-Meier analysis showed that patients with GOLPH3 overexpression had significantly poorer overall survival than those with low expression of GOLPH3 (log-rank P--.001). In the multivariate Cox proportional hazards analysis, GOLPH3 overexpression was independently associated with poorer overall survival (hazard ratio [HR]--.60; 95?% confidence interval (CI0 1.14-1.33, P--.03). Therefore, overexpression of GOLPH3 protein is closely related to poorer prognosis in patients with epithelial ovarian cancer.