Weight gain, overweight and obesity in solid organ transplantation—a study protocol for a systematic literature review

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• 作者：Sonja Beckmann (4)
  Nata?a Ivanovi? (4)
  Gerda Drent (5)
  Todd Ruppar (6)
  Sabina De Geest (4) (7)
  
  4. Institute of Nursing Science ; University of Basel ; Bernoullistrasse 28 ; CH-4056 ; Basel ; Switzerland
  5. Department of Gastroenterology and Hepatology ; University Medical Center Groningen ; University of Groningen ; PO box 30.001 ; 9700 ; RB ; Groningen ; the Netherlands
  6. Sinclair School of Nursing ; University of Missouri ; S423 ; Columbia ; MO ; 65211 ; USA
  7. Health Services and Nursing Research ; KU Leuven ; Kapucijnenvoer 35 ; B-3000 ; Leuven ; Belgium
  
• 关键词：Weight gain ; Overweight ; Obesity ; Survival ; Risk factors ; Outcomes ; Adult ; Transplantation ; Systematic review
• 刊名：Systematic Reviews
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：4
• 期：1
• 参考文献：1. World Health Organization: Obesity: preventing and managing the global epidemic. Report of a WHO consultation. / World Health Organ Tech Rep Ser 2000, 894:i-xii. 1-53
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  4. World Health Organization: / Obesity and overweight. . Accessed 08 Oct 2014 http://www.who.int/mediacentre/factsheets/fs311/en/index.html
  5. Sharma AM: Obesity and cardiovascular risk. / Growth Horm IGF Res 2003,13(A):S10-. CrossRef
  6. Donohoe CL, Pidgeon GP, Lysaght J, Reynolds JV: Obesity and gastrointestinal cancer. / Br J Surg 2010, 97:628-2. 10.1002/bjs.7079 CrossRef
  7. Flegal KM, Kit BK, Orpana H, Graubard BI: Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. / JAMA 2013, 309:71-2. 10.1001/jama.2012.113905 CrossRef
  8. Whitlock G, Lewington S, Sherliker P, Clarke R, Emberson J, Halsey J, / et al.: Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. / Lancet 2009, 373:1083-6. 10.1016/S0140-6736(09)60318-4 CrossRef
  9. Watt KD: Reducing the load: the evolution and management of obesity and nonalcoholic steatohepatitis before liver transplantation. / Liver Transpl 2012,18(Suppl 2):S52-. CrossRef
  10. Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C: Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. / Circulation 2004, 109:433-. 10.1161/01.CIR.0000111245.75752.C6 CrossRef
  11. Mottillo S, Filion KB, Genest J, Joseph L, Pilote L, Poirier P, / et al.: The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. / J Am Coll Cardiol 2010, 56:1113-2. 10.1016/j.jacc.2010.05.034 CrossRef
  12. Watt KD, Charlton MR: Metabolic syndrome and liver transplantation: a review and guide to management. / J Hepatol 2010, 53:199-06. 10.1016/j.jhep.2010.01.040 CrossRef
  13. Thomsen M, Nordestgaard BG: Myocardial infarction and ischemic heart disease in overweight and obesity with and without metabolic syndrome. / JAMA 2014,174(1):15-2.
  14. Hall KD, Heymsfield SB, Kemnitz JW, Klein S, Schoeller DA, Speakman JR: Energy balance and its components: implications for body weight regulation. / Am J Clin Nutr 2012,
• 刊物主题：Medicine/Public Health, general; Biomedicine general; Statistics for Life Sciences, Medicine, Health Sciences;
• 出版者：BioMed Central
• ISSN：2046-4053

文摘

Background Overweight and obesity, which have a substantial impact on health in the general population, have similar prevalence in solid organ transplant recipients but carry even more serious ramifications. As this group’s use of immunosuppressive medication increases the risk for comorbidities, e.g. metabolic syndrome and cardiovascular disease, the prevention of additional risk factors is vital. This systematic review will be the first to summarize the issue of weight gain, overweight and obesity concurrently within and across solid organ transplantation. The three research questions relating to solid organ transplantation are the following: (1) What are the prevalence and evolution of overweight and obesity from pre- to post-transplant?; (2) Which pre- and post-transplant risk factors are associated with post-transplant weight gain, overweight or obesity? and (3) Which post-transplant patient outcomes and comorbidities are associated with pre- and post-transplant weight gain, overweight and obesity? Methods/Design MEDLINE via PubMed, The Cochrane Library, Cumulative Index to Nursing and Allied Health (CINAHL), PsycINFO and Excerpta Medica DataBase (EMBASE) will be searched for original quantitative studies in adult liver, heart, lung or kidney transplant patients. Topics of interest will be the prevalence and evolution of overweight and obesity over time, risk factors associated with changes in weight or body mass index (BMI), overweight and obesity, and the relationship of weight or BMI with post-transplant outcomes and comorbidities. Screening of titles and abstracts, full-text reading and data extraction will be divided between three researchers. Researchers will cross-check one another’s screening decisions for random samples of studies to adhere as closely as possible to the recommendations of The Cochrane Collaboration. For quality assessment, a purpose-adapted 19-item instrument will be used. Effect sizes will be calculated for relationships investigated in a minimum of five studies. Random effects meta-analysis with moderator analyses will be conducted if applicable. Discussion This systematic review will comprehensively synthesize the existing evidence concerning weight gain, overweight and obesity in solid organ transplantation in view of magnitude, influencing factors and associations with patient outcomes and comorbidities. The results can fuel the development of interventions to prevent weight gain in the solid organ transplant population. Systematic review registration PROSPERO CRD42014009151