Three-component domino [3+2] heterocyclization leading to pyran-3-yl-substituted fused pyrroles

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• 作者：Shuang-Shuang Wang (1)
  Qi-Wei Zhu (1)
  Shuai Liu (1)
  Yang Yang (1)
  Zhi-Tong Wang (1)
  Bo Jiang (1)
  Shu-Jiang Tu (1)
  
  1. School of Chemistry and Chemical Engineering ; Jiangsu Normal University ; Xuzhou ; 221116 ; P. R. China
  
• 关键词：Heterocyclization ; Microwave irradiation ; Fused pyrroles ; Multicomponent reactions
• 刊名：Research on Chemical Intermediates
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：41
• 期：5
• 页码：2879-2889
• 全文大小：311 KB
• 参考文献：1. Tietze, LF, Brasche, G, Gerike, KM (2006) Domino Reactions in Organic Chemistry. Wiley-VCH, Weinheim
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• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Catalysis
  Physical Chemistry
  Inorganic Chemistry
  
• 出版者：Springer Netherlands
• ISSN：1568-5675

文摘

Concise and efficient three-component domino [3+2] heterocyclization to pyran-3-yl-substituted fused pyrroles promoted by HOAc have been developed under microwave irradiation. The reactions showed broad scopes of substrates which can employ a wide range of readily available arylglyoxal monohydrate and N-aryl enaminones. The structures of products 4 have been unambiguously determined by NMR and HRMS analyses. The single crystal of 4a was further confirmed by X-ray diffraction analysis.