Copper-catalyzed Meerwein carboarylation of alkenes with anilines to form 3-benzyl-3-alkyloxindole

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• 作者：Shi Tang (1) (2)
  Dong Zhou (1)
  YouLin Deng (1)
  ZhiHao Li (1)
  You Yang (1)
  JianGuang He (1)
  YingChun Wang (1) (3)
  
  1. College of Chemistry and Chemical Engineering ; Central South University ; Changsha ; 410083 ; China
  2. College of Chemistry and Chemical Engineering ; Jishou University ; Jishou ; 416000 ; China
  3. Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China) ; Guangxi Normal University ; Guilin ; 541004 ; China
  
• 关键词：radical reaction ; C ; H cyclization ; Meerwein arylation ; oxindole ; copper ; catalyzed
• 刊名：SCIENCE CHINA Chemistry
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：58
• 期：4
• 页码：684-688
• 全文大小：463 KB
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  41. The configuration and structures of the products 3e were unambiguously assigned by X-ray analysis. See Figure S3 in Supporting Information.
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• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Chinese Library of Science
  Chemistry
  
• 出版者：Science China Press, co-published with Springer
• ISSN：1869-1870

文摘

A simple and direct route for double C-C bond formation by copper-catalyzed Meerwein carboarylation process has been developed. In the presence of CuI (5 mol%), tert-butyl nitrite and anilines, a wide variety of N-arylacrylamides underwent tandem Meerwein arylation/C-H cyclization to produce pharmaceutically important 3-benzyl-3-alkyloxindole in moderate to good yield.