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Environmental aspects of congenital scoliosis
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  • 作者:Zheng Li (1)
    Xin Yu (1)
    Jianxiong Shen (1)

    1. Department of Orthopedic Surgery
    ; Peking Union Medical College Hospital ; Chinese Academy of Medical Science ; Peking Union Medical College ; 100730 ; Beijing ; China
  • 关键词:Congenital scoliosis ; Environmental ; Hypoxia ; Vitamin A deficiency
  • 刊名:Environmental Science and Pollution Research
  • 出版年:2015
  • 出版时间:April 2015
  • 年:2015
  • 卷:22
  • 期:8
  • 页码:5751-5755
  • 全文大小:149 KB
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  • 刊物类别:Earth and Environmental Science
  • 刊物主题:Environment
    Environment
    Atmospheric Protection, Air Quality Control and Air Pollution
    Waste Water Technology, Water Pollution Control, Water Management and Aquatic Pollution
    Industrial Pollution Prevention
  • 出版者:Springer Berlin / Heidelberg
  • ISSN:1614-7499
文摘
Growing evidence has proved that many aspects of our lifestyle and the environment contribute to the development of congenital disease. Congenital spinal deformities are due to anomalous development of the vertebrae including failure of formation and segmentation during embryogenesis. The causes of congenital scoliosis have not been fully identified. A variety of factors are implicated in the development of vertebral abnormalities. Previous studies have demonstrated that both genetics and environmental factors are implicated in the development of vertebral abnormalities. However, no specific cause for congenital scoliosis has been identified. In our review, we focus on the environmental factors for the development of congenital scoliosis. Various maternal exposures during pregnancy including hypoxia, alcohol use, vitamin deficiency, valproic acid, boric acid, and hyperthermia have been observed to be associated with the occurrence of congenital scoliosis. This review describes the major environmental contributors of congenital scoliosis with an emphasis on treatment aspects associated with environmental disposition in congenital scoliosis.

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