Downregulation of VGLL4 in the progression of esophageal squamous cell carcinoma

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• 作者：Wei Jiang (1)
  Feng Yao (2)
  Jing He (1)
  Bihong Lv (1)
  Wentao Fang (2)
  Weidong Zhu (1)
  Guangming He (1)
  Jianzhong Chen (1)
  Jianming He (1)
  
  1. Department of Thoracic Surgery ; Taixing People鈥檚 Hospital of Jiangsu Province ; 1 of Changzheng Rd ; Taixing City ; Jiangsu Province ; 225400 ; China
  2. Department of Thoracic Surgery ; Shanghai Chest Hospital ; Shanghai Jiao Tong University ; 241 West Huaihai Rd ; Shanghai ; 200030 ; China
  
• 关键词：ESCC ; VGLL4 ; CTGF ; Cell proliferation and migration
• 刊名：Tumor Biology
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：36
• 期：2
• 页码：1289-1297
• 全文大小：6,383 KB
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• 刊物主题：Cancer Research;
• 出版者：Springer Netherlands
• ISSN：1423-0380

文摘

VGLL4, a member of the Vestigial-like (VGLL) proteins, has been reported to be dysregulated in several cancer types. However, its function in esophageal squamous cell carcinoma (ESCC) remains poorly understood. Here, it was found that the expression level of VGLL4 was decreased in ESCC tissues. Moreover, forced expression of VGLL4 in ESCC cells inhibited cell growth and migration, while knockdown of VGLL4 expression promoted the tumorigenecity of ESCC cells. Mechanistically, VGLL4 regulated the growth and motility of ESCC cells through downregulating the expression of connective tissue growth factor (CTGF), a known oncogene in the progression of ESCC. Taken together, our study suggested that downregulation of VGLL4 was very important in the progression of ESCC, and restoring the function of VGLL4 might be a promising therapeutic strategy for ESCC.