Loss of Angiopoietin-like 7 diminishes the regeneration capacity of hematopoietic stem and progenitor cells

详细信息    查看全文

• 作者：Yiren Xiao (1) (2)
  Xinru Wei (1) (2)
  Zhiwu Jiang (1) (2)
  Xiangmeng Wang (3)
  Wei Ye (1) (2)
  Xin Liu (4)
  Minjie Zhang (4)
  Yan Xu (5) (6)
  Donghai Wu (1) (2)
  Liangxue Lai (1) (2)
  Huihui Yao (7)
  Zixia Liu (8)
  Su Cao (9)
  Pentao Liu (10)
  Bing Xu (3)
  Yangqiu Li (5) (6)
  Yao Yao (11)
  Duanqing Pei (1) (2)
  Peng Li (1) (2)
  
  1. Key Laboratory of Regenerative Biology ; South China Institute for Stem Cell Biology and Regenerative Medicine ; Guangzhou Institutes of Biomedicine and Health ; Chinese Academy of Sciences ; 190 Kaiyuan Avenue ; Science Park ; Guangzhou ; 7 ; Guangdong ; 510530 ; China
  2. Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine ; South China Institute for Stem Cell Biology and Regenerative Medicine ; Guangzhou Institutes of Biomedicine and Health ; Chinese Academy of Sciences ; Guangzhou ; 510530 ; China
  3. Department of Hematology ; Nanfang Hospital ; Southern Medical University ; 510515 ; Guangzhou ; China
  4. Shenzhen Institutes of Advanced Technology ; Chinese Academy of Sciences ; 1068 Xueyuan Avenue ; Shenzhen University Town ; Shenzhen ; 518055 ; China
  5. Institute of Hematology ; Medical College ; Jinan University ; Guangzhou ; 510632 ; China
  6. Key Laboratory for Regenerative Medicine of Ministry of Education ; Jinan University ; Guangzhou ; 510632 ; China
  7. Department of Outpatient ; The 91th Military Hospital ; 454003 ; Jiaozuo ; China
  8. Division of Reproductive Endocrinology ; The 91th Military Hospital ; 454003 ; Jiaozuo ; China
  9. Division of General Pediatrics ; The 91th Military Hospital ; 454003 ; Jiaozuo ; China
  10. Wellcome Trust Sanger Institute ; Hinxton ; Cambridge CB10 1HH ; England ; UK
  11. Drug Discovery Pipeline ; Guangzhou Institutes of Biomedicine and Health ; Chinese Academy of Sciences ; Guangzhou ; 510530 ; China
  
• 关键词：Angptl7 ; Knockout ; mice ; Hematopoietic stem cell ; Repopulation ; Homing
• 刊名：Journal of Hematology & Oncology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：8
• 期：1
• 全文大小：2,015 KB
• 参考文献：1. Attal, M, Harousseau, JL, Stoppa, AM, Sotto, JJ, Fuzibet, JG, Rossi, JF (1996) A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. Intergroupe Francais du Myelome. N Engl J Med 335: pp. 91-7 113350204" target="_blank" title="It opens in new window">CrossRef
  2. Lin, R, Liu, Q (2013) Diagnosis and treatment of viral diseases in recipients of allogeneic hematopoietic stem cell transplantation. J Hematol Oncol 6: pp. 94 1186/1756-8722-6-94" target="_blank" title="It opens in new window">CrossRef
  3. Liao, W, Aguila, JR, Yao, Y, Yang, J, Zieve, G, Jiang, Y (2013) Enhancing bone marrow regeneration by SALL4 protein. J Hematol Oncol 6: pp. 84 1186/1756-8722-6-84" target="_blank" title="It opens in new window">CrossRef
  4. Gschweng, E, Oliveira, S, Kohn, DB (2014) Hematopoietic stem cells for cancer immunotherapy. Immunol Rev 257: pp. 237-49 1111/imr.12128" target="_blank" title="It opens in new window">CrossRef
  5. Kharfan-Dabaja, MA, Hamadani, M, Reljic, T, Nishihori, T, Bensinger, W, Djulbegovic, B (2013) Comparative efficacy of tandem autologous versus autologous followed by allogeneic hematopoietic cell transplantation in patients with newly diagnosed multiple myeloma: a systematic review and meta-analysis of randomized controlled trials. J Hematol Oncol 6: pp. 2 1186/1756-8722-6-2" target="_blank" title="It opens in new window">CrossRef
  6. Hato, T, Tabata, M, Oike, Y (2008) The role of angiopoietin-like proteins in angiogenesis and metabolism. Trends Cardiovasc Med 18: pp. 6-14 CrossRef
  7. Ikushima, YM, Arai, F, Nakamura, Y, Hosokawa, K, Kubota, Y, Hirashima, M (2013) Enhanced Angpt1/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells. Biochem Biophys Res Commun 430: pp. 20-5 11.002" target="_blank" title="It opens in new window">CrossRef
  8. Zhang, CC, Kaba, M, Ge, G, Xie, K, Tong, W, Hug, C (2006) Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells. Nat Med 12: pp. 240-5 CrossRef
  9. Zheng, J, Umikawa, M, Cui, C, Li, J, Chen, X, Zhang, C, Huynh, H, Kang, X, Silvany, R, Wan, X (2012) Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development. Nature 485: pp. 656-60 11095" target="_blank" title="It opens in new window">CrossRef
  10. Comes, N, Buie, LK, Borras, T (2011) Evidence for a role of angiopoietin-like 7 (ANGPTL7) in extracellular matrix formation of the human trabecular meshwork: implications for glaucoma. Genes Cells 16: pp. 243-59 1111/j.1365-2443.2010.01483.x" target="_blank" title="It opens in new window">CrossRef
  11. Huang, XJ (2008) Current status of haploidentical stem cell transplantation for leukemia. J Hematol Oncol 1: pp. 27 1186/1756-8722-1-27" target="_blank" title="It opens in new window">CrossRef
  12. Toyama, H, Arai, F, Hosokawa, K, Ikushima, YM, Suda, T (2012) N-cadherin鈥?鈥塇SCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin- HSCs. Biochem Biophys Res Commun 428: pp. 354-9 CrossRef
  13. Sugiyama, D, Kulkeaw, K, Mizuochi, C, Horio, Y, Okayama, S (2011) Hepatoblasts comprise a niche for fetal liver erythropoiesis through cytokine production. Biochem Biophys Res Commun 410: pp. 301-6 11.05.137" target="_blank" title="It opens in new window">CrossRef
  14. Morrison, SJ, Hemmati, HD, Wandycz, AM, Weissman, IL (1995) The Purification and Characterization of Fetal Liver Hematopoietic Stem-Cells. Proc Natl Acad Sci U S A 92: pp. 10302-6 CrossRef
  15. Wang, L, Xiao, H, Zhang, X, Wang, C, Huang, H (2014) The role of telomeres and telomerase in hematologic malignancies and hematopoietic stem cell transplantation. J Hematol Oncol 7: pp. 61 1186/s13045-014-0061-9" target="_blank" title="It opens in new window">CrossRef
  
• 刊物主题：Oncology; Hematology; Cancer Research;
• 出版者：BioMed Central
• ISSN：1756-8722

文摘

Successful expansion of hematopoietic stem cells (HSCs) would benefit the use of HSC transplants in the clinic. Angiopoietin-like 7 promotes the expansion of hematopoietic stem and progenitor cells (HSPC) in vitro and ex vivo. However, the impact of loss of Angptl7 on HSPCs in vivo has not been characterized. Here, we generated Angptl7-deficient mice by TALEN-mediated gene targeting and found that HSC compartments in Angptl7-null mice were compromised. In addition, wild type (WT) HSPCs failed to repopulate in the BM of Angptl7-null mice after serial transplantations while the engraftment of Angptl7-deficient HSPCs in WT mice was not impaired. These results suggest that Angptl7 is required for HSPCs repopulation in a non-cell autonomous manner.