Osteoporosis increases subsequent risk of gallstone: a nationwide population-based cohort study in Taiwan

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• 作者：Sukhontip Klahan (1)
  Chun-Nan Kuo (1) (2)
  Shu-Chen Chien (1) (3)
  Yea-Wen Lin (4)
  Chun-Yi Lin (4)
  Chia-Hsien Lin (5)
  Wei-Chiao Chang (1) (2) (7) (8)
  Ching-I Lin (9)
  Kuo-Sheng Hung (10) (6) (7)
  Wei-Pin Chang (4)
  
  1. Department of Clinical Pharmacy ; School of Pharmacy ; Taipei Medical University ; Taipei ; Taiwan
  2. Department of Pharmacy ; Taipei Medical University-Wan Fang Hospital ; Taipei ; Taiwan
  3. Department of Pharmacy ; Taipei Medical University Hospital ; Taipei ; Taiwan
  4. Department of Healthcare Management ; Yuanpei University of Medical Technology ; HsinChu ; Taiwan
  5. Department of Health Industry Management ; Kainan University ; Taoyuan ; Taiwan
  7. Master Program for Clinical Pharmacogenomics and Pharmacoproteomics ; School of Pharmacy ; Taipei Medical University ; Taipei ; Taiwan
  8. Graduate Institute of Pharmacognosy ; Taipei Medical University ; Taipei ; Taiwan
  9. Department of Nutrition and Health Sciences ; Kainan University ; Taoyuan ; Taiwan
  10. Comprehensive Cancer Center of Taipei Medical University ; Taipei ; Taiwan
  6. Department of Neurosurgery ; Clinical Research Center ; Graduate Institute of Injury Prevention and Control ; Taipei Medical University ; Wan Fang Hospital ; Taipei ; Taiwan
  
• 关键词：Osteoporosis ; Gallstone ; Population ; based study ; Taiwan
• 刊名：BMC Gastroenterology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：14
• 期：1
• 全文大小：302 KB
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• 刊物主题：Gastroenterology; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-230X

文摘

Background Osteopontin (OPN) is a pro-inflammatory cytokine which is expressed in various tissues. It participates in the bone remodeling process and stimulates bone resorption by osteoclasts. It is also a core protein of cholesterol gallstones. We hypothesized osteoporotic patients might have higher risk in developing gallstones and conducted a population-based study to examine the risk of developing gallstone in osteoporotic patients in Taiwan. Methods A total of 1,638 patients diagnosed with osteoporosis between 2003 and 2005 were identified in the National Health Insurance Research Database. A comparison cohort without osteoporosis (n =6,552) was randomly matched to each osteoporosis patient at a ratio of 4: 1 based on age and sex. A Cox proportional-hazards regression analysis was performed to evaluate the 5-year gallstone-free survival rates for the 2 cohorts. Results During the 5-year follow-up period, 114 and 311 cases of gallstone occurred in the osteoporosis and comparison cohorts, respectively. After adjusting for the confounders, the Cox regression analysis of the risk of gallstone in the osteoporosis and comparison cohorts yielded a hazard ratio of 1.35 (95% confidence interval: 1.07 - 1.69; p Conclusion Patients with osteoporosis in Taiwan have a higher risk of developing gallstone than the general population.