Levels of HOXB7 and miR-337 in pancreatic ductal adenocarcinoma patients

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• 作者：Rui Zhang (1)
  Shangen Zheng (2)
  Yuwen Du (3)
  Yuanyuan Wang (3)
  Wenqiao Zang (3)
  Guoqiang Zhao (3)
  
  1. Department of emergency ; The First Affiliated Hospital of Zhengzhou University ; No.1 Jianshe Road ; Zhengzhou ; Henan ; 450052 ; China
  2. Department of Blood Transfusion ; Wuhan General Hospital of Guangzhou Military Command ; Wuhan ; Hubei ; 430070 ; China
  3. College of Basic Medical Sciences ; Zhengzhou University ; No.100 Kexue Road ; Zhengzhou ; 450001 ; China
  
• 关键词：Pancreatic ductal adenocarcinoma (PDAC) ; HOXB7 ; miR ; 337
• 刊名：Diagnostic Pathology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：9
• 期：1
• 全文大小：475 KB
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• 刊物主题：Pathology;
• 出版者：BioMed Central
• ISSN：1746-1596

文摘

Background Many studies have revealed that homeobox-B7 (HOXB7) and miR-337 play important roles in different types of human cancers. However, the relationship of HOXB7 and miR-337 in PDAC with clinicopathological factors has not yet been examined and their biological roles remain to be explored. Methods Using quantitative real-time RT-PCR and immunohistochemical staining, the expression of HOXB7 mRNA, miR-337, and HOXB7 protein in 44 PDAC samples was detected. Survival curves were made using follow-up data. The relationship between clinical or pathological characteristics and the prognosis was analyzed. Results The expression levels of HOXB7 mRNA and HOXB7 protein were significantly elevated in PDAC samples than that in non-malignant adjacent tissues. There were obvious differences in HOXB7 mRNA and proteins between tumors of different diameters, differentiation, TNM stage, and lymph node status. The level of miR-337 was markedly lower in tumor samples than in non-malignant adjacent tissues. The expression of miR-337 was related to TNM stage and lymph node status. There were significant differences in survival curves between patients with tumors mRNA, HOXB7 protein, and miR-337 were found to be associated with longer survival. Conclusion The present study showed that HOXB7 was over-expressed and miR-337 was minimally expressed in PDAC tissues, and their levels were related to TNM stage and lymph node status. The levels of HOXB7 mRNA, HOXB7 protein, and miR-337 were associated with survival in PDAC patients. Results suggested that HOXB7 and miR-337 could be used as determinants of PDAC patient prognosis. Virtual slides The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1509730773118658.