Cancer stem-like cell: a novel target for nasopharyngeal carcinoma therapy

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• 作者：Pingpin Wei (5) (7)
  Man Niu (5) (7)
  Suming Pan (5) (6)
  Yanhong Zhou (5) (7)
  Cijun Shuai (7)
  Jing Wang (7)
  Shuping Peng (5) (7)
  Guiyuan Li (5) (7)
  
  5. Cancer Research Institute of Xiangya Medical School ; Central South University ; 110 Xiangya Road ; Changsha ; Hunan ; 410078 ; China
  7. State Key Laboratory of High Performance Complex Manufacturing ; Central South University ; 932 South Yeulu Mountain Road ; Changsha ; Hunan ; 410083 ; China
  6. Guandong Provincial Yuebei People鈥檚 Hospital ; 133 Huimin South Road ; Shaoguan ; Guangdong ; 512025 ; China
  
• 刊名：Stem Cell Research & Therapy
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：5
• 期：2
• 全文大小：326 KB
• 参考文献：1. Lung, HL, Cheung, AK, Xie, D, Cheng, Y, Kwong, FM, Murakami, Y, Guan, XY, Sham, JS, Chua, D, Protopopov, AI, Zabarovsky, ER, Tsao, SW, Stanbridge, EJ, Lung, ML (2006) TSLC1 is a tumor suppressor gene associated with metastasis in nasopharyngeal carcinoma. Cancer Res 66: pp. 9385-9392 CrossRef
  2. Kong, L, Zhang, YW, Hu, CS, Guo, Y (2012) Neoadjuvant chemotherapy followed by concurrent chemoradiation for locally advanced nasopharyngeal carcinoma. Chin J Cancer 29: pp. 551-555 CrossRef
  3. Nor Hashim, NA, Ramzi, NH, Velapasamy, S, Alex, L, Chahil, JK, Lye, SH, Munretnam, K, Haron, MR, Ler, LW (2012) Identification of genetic and non-genetic risk factors for nasopharyngeal carcinoma in a Southeast Asian population. Asian Pac J Cancer Prev 13: pp. 6005-6010 CrossRef
  4. Chua, DT, Sham, JS, Kwong, DL, Au, GK (2003) Treatment outcome after radiotherapy alone for patients with stage I鈥揑I nasopharyngeal carcinoma. Cancer 98: pp. 74-80 CrossRef
  5. Ma, J, Mai, HQ, Hong, MH, Min, HQ, Mao, ZD, Cui, NJ, Lu, TX, Mo, HY (2001) Results of a prospective randomized trial comparing neoadjuvant chemotherapy plus radiotherapy with radiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma. J Clin Oncol 19: pp. 1350-1357
  6. Xu, T, Tang, J, Gu, M, Liu, L, Wei, W, Yang, H (2013) Recurrent nasopharyngeal carcinoma: a clinical dilemma and challenge. Curr Oncol 20: pp. e406-e419 CrossRef
  7. Li, JX, Lu, TX, Huang, Y, Han, F (2012) Clinical characteristics of recurrent nasopharyngeal carcinoma in high-incidence area. Sci World J 2012: pp. 719754
  8. Lapidot, T, Sirard, C, Vormoor, J, Murdoch, B, Hoang, T, Caceres-Cortes, J, Minden, M, Paterson, B, Caligiuri, MA, Dick, JE (1994) A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367: pp. 645-648 CrossRef
  9. Reya, T, Morrison, SJ, Clarke, MF, Weissman, IL (2001) Stem cells, cancer, and cancer stem cells. Nature 414: pp. 105-111 CrossRef
  10. Trumpp, A, Wiestler, OD (2008) Mechanisms of disease: cancer stem cells 鈥?targeting the evil twin. Nat Clin Pract Oncol 5: pp. 337-347
  11. Singh, SK, Hawkins, C, Clarke, ID, Squire, JA, Bayani, J, Hide, T, Henkelman, RM, Cusimano, MD, Dirks, PB (2004) Identification of human brain tumour initiating cells. Nature 432: pp. 396-401 CrossRef
  12. Al-Hajj, M, Wicha, MS, Benito-Hernandez, A, Morrison, SJ, Clarke, MF (2003) Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A 100: pp. 3983-3988 CrossRef
  13. Dalerba, P, Dylla, SJ, Park, IK, Liu, R, Wang, X, Cho, RW, Hoey, T, Gurney, A, Huang, EH, Simeone, DM, Shelton, AA, Parmiani, G, Castelli, C, Clarke, MF (2007) Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A 104: pp. 10158-10163 CrossRef
  14. O'Brien, CA, Pollett, A, Gallinger, S, Dick, JE (2007) A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445: pp. 106-110 CrossRef
  15. Hermann, PC, Huber, SL, Herrler, T, Aicher, A, Ellwart, JW, Guba, M, Bruns, CJ, Heeschen, C (2007) Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 1: pp. 313-323 CrossRef
  16. Li, C, Heidt, DG, Dalerba, P, Burant, CF, Zhang, L, Adsay, V, Wicha, M, Clarke, MF, Simeone, DM (2007) Identification of pancreatic cancer stem cells. Cancer Res 67: pp. 1030-1037 CrossRef
  17. Zhang, HB, Ren, CP, Yang, XY, Wang, L, Li, H, Zhao, M, Yang, H, Yao, KT (2007) Identification of label-retaining cells in nasopharyngeal epithelia and nasopharyngeal carcinoma tissues. Histochem Cell Biol 127: pp. 347-354 CrossRef
  18. Jiang, QP, Yao, KT (2010) Isolation and detection of label-retaining cells in a nasopharyngeal carcinoma cell line. Chin J Cancer 29: pp. 572-574 CrossRef
  19. Wang, WJ, Wu, SP, Liu, JB, Shi, YS, Huang, X, Zhang, QB, Yao, KT (2013) MYC regulation of CHK1 and CHK2 promotes radioresistance in a stem cell-like population of nasopharyngeal carcinoma cells. Cancer Res 73: pp. 1219-1231 CrossRef
  20. Zhao, Y, Bao, Q, Schwarz, B, Zhao, L, Mysliwietz, J, Ellwart, J, Renner, A, Hirner, H, Niess, H, Camaj, P, Angele, M, Gros, S, Izbicki, J, Jauch, KW, Nelson, PJ, Bruns, CJ (2014) Stem cell-like side populations in esophageal cancer: a source of chemotherapy resistance and metastases. Stem Cells Dev 23: pp. 180-192 CrossRef
  21. Britton, KM, Kirby, JA, Lennard, TW, Meeson, AP (2011) Cancer stem cells and side population cells in breast cancer and metastasis. Cancers (Basel) 3: pp. 2106-2130 CrossRef
  22. Hosonuma, S, Kobayashi, Y, Kojo, S, Wada, H, Seino, K, Kiguchi, K, Ishizuka, B (2011) Clinical significance of side population in ovarian cancer cells. Hum Cell 24: pp. 9-12 CrossRef
  23. Kabashima, A, Higuchi, H, Takaishi, H, Matsuzaki, Y, Suzuki, S, Izumiya, M, Iizuka, H, Sakai, G, Hozawa, S, Azuma, T, Hibi, T (2009) Side population of pancreatic cancer cells predominates in TGF-beta-mediated epithelial to mesenchymal transition and invasion. Int J Cancer 124: pp. 2771-2779 CrossRef
  24. Shi, GM, Xu, Y, Fan, J, Zhou, J, Yang, XR, Qiu, SJ, Liao, Y, Wu, WZ, Ji, Y, Ke, AW, Ding, ZB, He, YZ, Wu, B, Yang, GH, Qin, WZ, Zhang, W, Zhu, J, Min, ZH, Wu, ZQ (2008) Identification of side population cells in human hepatocellular carcinoma cell lines with stepwise metastatic potentials. J Cancer Res Clin Oncol 134: pp. 1155-1163 CrossRef
  25. Wang, J, Guo, LP, Chen, LZ, Zeng, YX, Lu, SH (2007) Identification of cancer stem cell-like side population cells in human nasopharyngeal carcinoma cell line. Cancer Res 67: pp. 3716-3724 CrossRef
  26. Zhang, H, Liu, W, Feng, X, Wang, L, Jiang, X, Liu, D, Zhang, L, Zhu, B, Zhou, W, Jia, W, Li, G, Ren, C (2012) Identification of ABCG2(+) cells in nasopharyngeal carcinoma cells. Oncol Rep 27: pp. 1177-1187
  27. Patrawala, L, Calhoun, T, Schneider-Broussard, R, Zhou, J, Claypool, K, Tang, DG (2005) Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2鈭?cancer cells are similarly tumorigenic. Cancer Res 65: pp. 6207-6219 CrossRef
  28. Magni, M, Shammah, S, Schir贸, R, Mellado, W, Dalla-Favera, R, Gianni, AM (1996) Induction of cyclophosphamide-resistance by aldehyde-dehydrogenase gene transfer. Blood 87: pp. 1097-1103
  29. Wu, A, Luo, W, Zhang, Q, Yang, Z, Zhang, G, Li, S, Yao, K (2013) Aldehyde dehydrogenase 1, a functional marker for identifying cancer stem cells in human nasopharyngeal carcinoma. Cancer Lett 330: pp. 181-189 CrossRef
  30. Luo, WR, Gao, F, Li, SY, Yao, KT (2012) Tumour budding and the expression of cancer stem cell marker aldehyde dehydrogenase 1 in nasopharyngeal carcinoma. Histopathology 61: pp. 1072-1081 CrossRef
  31. Yu, F, Sim, AC, Li, C, Li, Y, Zhao, X, Wang, DY, Loh, KS (2013) Identification of a subpopulation of nasopharyngeal carcinoma cells with cancer stem-like cell properties by high aldehyde dehydrogenase activity. Laryngoscope 123: pp. 1903-1911 CrossRef
  32. You, X, Yang, YC (2013) [Research progress of separation screening and oncogenes correlation in nasopharyngeal carcinoma cancer stem cells]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 48: pp. 254-257
  33. Hou, W, He, W, Li, Y, Ma, R, Wang, Z, Zhu, X, Fu, Q, Wen, Y, Li, H, Wen, W (2014) Increased expression of aldehyde dehydrogenase 1 A1 in nasopharyngeal carcinoma is associated with enhanced invasiveness. Eur Arch Otorhinolaryngol 271: pp. 171-179 CrossRef
  34. Li, F, Tiede, B, Massagu茅, J, Kang, Y (2007) Beyond tumorigenesis: cancer stem cells in metastasis. Cell Res 17: pp. 3-14 CrossRef
  35. Patrawala, L, Calhoun, T, Schneider-Broussard, R, Li, H, Bhatia, B, Tang, S, Reilly, JG, Chandra, D, Zhou, J, Claypool, K, Coghlan, L, Tang, DG (2006) Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells. Oncogene 25: pp. 1696-1708 CrossRef
  36. Su, J, Xu, XH, Huang, Q, Lu, MQ, Li, DJ, Xue, F, Yi, F, Ren, JH, Wu, YP (2011) Identification of cancer stem-like CD44+ cells in human nasopharyngeal carcinoma cell line. Arch Med Res 42: pp. 15-21 CrossRef
  37. Janisiewicz, AM, Shin, JH, Murillo-Sauca, O, Kwok, S, Le, QT, Kong, C, Kaplan, MJ, Sunwoo, JB (2012) CD44(+) cells have cancer stem cell-like properties in nasopharyngeal carcinoma. Int Forum Allergy Rhinol 2: pp. 465-470 CrossRef
  38. Allegra, E, Trapasso, S (2012) Cancer stem cells in head and neck cancer. Onco Targets Ther 5: pp. 375-383 CrossRef
  39. Trapasso, S, Allegra, E (2012) Role of CD44 as a marker of cancer stem cells in head and neck cancer. Biologics 6: pp. 379-383
  40. Zhuang, HW, Mo, TT, Hou, WJ, Xiong, GX, Zhu, XL, Fu, QL, Wen, WP (2013) Biological characteristics of CD133+ cells in nasopharyngeal carcinoma. Oncol Rep 30: pp. 57-63
  41. Deng, CC, Liang, Y, Wu, MS, Feng, FT, Hu, WR, Chen, LZ, Feng, QS, Bei, JX, Zeng, YX (2013) Nigericin selectively targets cancer stem cells in nasopharyngeal carcinoma. Int J Biochem Cell Biol 45: pp. 1997-2006 CrossRef
  42. Allegra, E, Puzzo, L, Zuccal脿, V, Trapasso, S, Vasquez, E, Garozzo, A, Caltabiano, R (2012) Nuclear BMI-1 expression in laryngeal carcinoma correlates with lymph node pathological status. World J Surg Oncol 10: pp. 206 CrossRef
  43. Allegra, E, Caltabiano, R, Amorosi, A, Vasquez, E, Garozzo, A, Puzzo, L (2012) Expression of BMI1 and p16 in laryngeal squamous cell carcinoma. Head Neck 35: pp. 847-851 CrossRef
  44. Singh, SK, Clarke, ID, Terasaki, M, Bonn, VE, Hawkins, C, Squire, J, Dirks, PB (2003) Identification of a cancer stem cell in human brain tumors. Cancer Res 63: pp. 5821-5828
  45. Fang, D, Nguyen, TK, Leishear, K, Finko, R, Kulp, AN, Hotz, S, Van Belle, PA, Xu, X, Elder, DE, Herlyn, M (2005) A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res 65: pp. 9328-9337 CrossRef
  46. Ponti, D, Costa, A, Zaffaroni, N, Pratesi, G, Petrangolini, G, Coradini, D, Pilotti, S, Pierotti, MA, Daidone, MG (2005) Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res 65: pp. 5506-5511 CrossRef
  47. Zhang, S, Balch, C, Chan, MW, Lai, HC, Matei, D, Schilder, JM, Yan, PS, Huang, TH, Nephew, KP (2008) Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Res 68: pp. 4311-4320 CrossRef
  48. Fujii, H, Honoki, K, Tsujiuchi, T, Kido, A, Yoshitani, K, Takakura, Y (2009) Sphere-forming stem-like cell populations with drug resistance in human sarcoma cell lines. Int J Oncol 34: pp. 1381-1386
  49. Lun, SW, Cheung, ST, Cheung, PF, To, KF, Woo, JK, Choy, KW, Chow, C, Cheung, CC, Chung, GT, Cheng, AS, Ko, CW, Tsao, SW, Busson, P, Ng, MH, Lo, KW (2012) CD44+ cancer stem-like cells in EBV-associated nasopharyngeal carcinoma. PLoS One 7: pp. e52426 CrossRef
  50. Raab-Traub, N (2002) Epstein鈥揃arr virus in the pathogenesis of NPC. Semin Cancer Biol 12: pp. 431-441 CrossRef
  51. Pathmanathan, R, Prasad, U, Sadler, R, Flynn, K, Raab-Traub, N (1995) Clonal proliferations of cells infected with Epstein鈥揃arr virus in preinvasive lesions related to nasopharyngeal carcinoma. N Engl J Med 333: pp. 693-698 CrossRef
  52. Niedobitek, G, Agathanggelou, A, Herbst, H, Whitehead, L, Wright, DH, Young, LS (1997) Epstein鈥揃arr virus (EBV) infection in infectious mononucleosis: virus latency, replication and phenotype of EBV-infected cells. J Pathol 182: pp. 151-159 CrossRef
  53. Niedobitek, G, Agathanggelou, A, Steven, N, Young, LS (2000) Epstein鈥揃arr virus (EBV) in infectious mononucleosis: detection of the virus in tonsillar B lymphocytes but not in desquamated oropharyngeal epithelial cells. Mol Pathol 53: pp. 37-42 CrossRef
  54. Chen, HL, Peng, J, Zhu, XB, Gao, J, Xue, JL, Wang, MW, Xia, HS (2013) Detection of EBV in nasopharyngeal carcinoma by quantum dot fluorescent in situ hybridization. Exp Mol Pathol 89: pp. 367-371 CrossRef
  55. Horikawa, T, Yang, J, Kondo, S, Yoshizaki, T, Joab, I, Furukawa, M, Pagano, JS (2007) Twist and epithelial鈥搈esenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma. Cancer Res 67: pp. 1970-1978 CrossRef
  56. Kong, QL, Hu, LJ, Cao, JY, Huang, YJ, Xu, LH, Liang, Y, Xiong, D, Guan, S, Guo, BH, Mai, HQ, Chen, QY, Zhang, X, Li, MZ, Shao, JY, Qian, CN, Xia, YF, Song, LB, Zeng, YX, Zeng, MS (2010) Epstein鈥揃arr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. PLoS Pathog 6: pp. e1000940 CrossRef
  57. Pegtel, DM, Subramanian, A, Sheen, TS, Tsai, CH, Golub, TR, Thorley-Lawson, DA (2005) Epstein鈥揃arr-virus-encoded LMP2A induces primary epithelial cell migration and invasion: possible role in nasopharyngeal carcinoma metastasis. J Virol 79: pp. 15430-15442 CrossRef
  58. Hugo, H, Ackland, ML, Blick, T, Lawrence, MG, Clements, JA, Williams, ED, Thompson, EW (2007) Epithelial鈥搈esenchymal and mesenchymal鈥揺pithelial transitions in carcinoma progression. J Cell Physiol 213: pp. 374-383 CrossRef
  59. Sarkar, FH, Li, Y, Wang, Z, Kong, D (2010) The role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancer. Cancer Metastasis Rev 29: pp. 383-394 CrossRef
  60. Singh, A, Settleman, J (2010) EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 29: pp. 4741-4751 CrossRef
  61. Wang, Z, Li, Y, Ahmad, A, Azmi, AS, Kong, D, Banerjee, S, Sarkar, FH (2010) Targeting miRNAs involved in cancer stem cell and EMT regulation: an emerging concept in overcoming drug resistance. Drug Resist Updat 13: pp. 109-118 CrossRef
  62. Brabletz, T, Jung, A, Spaderna, S, Hlubek, F, Kirchner, T (2005) Opinion: migrating cancer stem cells 鈥?an integrated concept of malignant tumour progression. Nat Rev Cancer 5: pp. 744-749 CrossRef
  63. Shen, YA, Lin, CH, Chi, WH, Wang, CY, Hsieh, YT, Wei, YH, Chen, YJ (2013) Resveratrol impedes the stemness, epithelial鈥搈esenchymal transition, and metabolic reprogramming of cancer stem cells in nasopharyngeal carcinoma through p53 activation. Evid Based Complement Alternat Med 2013: pp. 590393
  64. Lin, CH, Shen, YA, Hung, PH, Yu, YB, Chen, YJ (2012) Epigallocathechin gallate, polyphenol present in green tea, inhibits stem-like characteristics and epithelial鈥搈esenchymal transition in nasopharyngeal cancer cell lines. BMC Complement Altern Med 12: pp. 201 CrossRef
  65. Wu, MS, Wang, GF, Zhao, ZQ, Liang, Y, Wang, HB, Wu, MY, Min, P, Chen, LZ, Feng, QS, Bei, JX, Zeng, YX, Yang, D (2013) Smac mimetics in combination with TRAIL selectively target cancer stem cells in nasopharyngeal carcinoma. Mol Cancer Ther 12: pp. 1728-1737 CrossRef
  66. Yu, S, Zhang, R, Liu, F, Wang, H, Wu, J, Wang, Y (2012) Notch inhibition suppresses nasopharyngeal carcinoma by depleting cancer stem-like side population cells. Oncol Rep 28: pp. 561-566
  67. Ma, L, Zhang, G, Miao, XB, Deng, XB, Wu, Y, Liu, Y, Jin, ZR, Li, XQ, Liu, QZ, Sun, DX, Testa, JR, Yao, KT, Xiao, GH (2013) Cancer stem-like cell properties are regulated by EGFR/AKT/beta-catenin signaling and preferentially inhibited by gefitinib in nasopharyngeal carcinoma. Febs J 280: pp. 2027-2041 CrossRef
  68. Port, RJ, Pinheiro-Maia, S, Hu, C, Arrand, JR, Wei, W, Young, LS, Dawson, CW (2013) Epstein鈥揃arr virus induction of the Hedgehog signalling pathway imposes a stem cell phenotype on human epithelial cells. J Pathol 231: pp. 367-377
  69. Yue, Y, Zhong, W, Pei, G, Xiao, B, Zhang, G, Jiang, F, Zhang, J, Chen, C, Yang, P, Dang, H, Chang, H (2013) Aberrant activation of Hedgehog pathway in nasopharyngeal carcinoma. Clin Exp Med 13: pp. 315-322 CrossRef
  70. Golebiewska, A, Bougnaud, S, Stieber, D, Brons, NH, Vallar, L, Hertel, F, Klink, B, Schr枚ck, E, Bjerkvig, R, Niclou, SP (2013) Side population in human glioblastoma is non-tumorigenic and characterizes brain endothelial cells. Brain 136: pp. 1462-1475 CrossRef
  71. Wang, YC, Yo, YT, Lee, HY, Liao, YP, Chao, TK, Su, PH, Lai, HC (2012) ALDH1-bright epithelial ovarian cancer cells are associated with CD44 expression, drug resistance, and poor clinical outcome. Am J Pathol 180: pp. 1159-1169 CrossRef
  72. Neumeister, V, Agarwal, S, Bordeaux, J, Camp, RL, Rimm, DL (2010) In situ identification of putative cancer stem cells by multiplexing ALDH1, CD44, and cytokeratin identifies breast cancer patients with poor prognosis. Am J Pathol 176: pp. 2131-2138 CrossRef
  
• 刊物主题：Stem Cells; Cell Biology;
• 出版者：BioMed Central
• ISSN：1757-6512

文摘

Nasopharyngeal carcinoma (NPC) is the most common cancer originating in the nasopharynx, and is extremely common in southern regions of China. Although the standard combination of radiotherapy and chemotherapy has improved the efficiency in patients with NPC, relapse and early metastasis are still the common causes of mortality. Cancer stem-like cells (CSCs) or tumor initial cells are hypothesized to be involved in cancer metastasis and recurrence. Over the past decade, increasing numbers of studies have been carried out to identify CSCs from human NPC cells and tissues. The present paper will summarize the investigations on nasopharyngeal CSCs, including isolation, characteristics, and therapeutic approaches. Although there are still numerous challenges to translate basic research into clinical applications, understanding the molecular details of CSCs is essential for developing effective strategies to prevent the recurrence and metastasis of NPC.