Apoptin as a Potential Viral Gene Oncotherapeutic Agent

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• 作者：Prafull Kumar Singh ; Dr. Ashok K. Tiwari…
• 关键词：Apoptin ; Apoptosis ; VP3 ; Viral gene oncotherapy
• 刊名：Applied Biochemistry and Biotechnology
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：176
• 期：1
• 页码：196-212
• 全文大小：1,628 KB
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• 作者单位：Prafull Kumar Singh (1)
  Dr. Ashok K. Tiwari (1)
  R. S. Rajmani (1)
  G. Ravi Kumar (1)
  Uttara Chaturvedi (1)
  Lovleen Saxena (1)
  Shikha Saxena (1)
  Juwar Doley (1)
  Aditya Prasad Sahoo (1)
  Lakshman Santra (1)
  Meeta Saxena (2)
  Sudesh Kumar (1)
  Bhaskar Sharma (2)
  
  1. Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, Bareilly, 243122, India
  2. Division of Biochemistry and Food Science section, Indian Veterinary Research Institute, Izatnagar, Bareilly, 243122, India
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Biotechnology
  Biochemistry
  
• 出版者：Humana Press Inc.
• ISSN：1559-0291

文摘

The use of viruses for treatment of cancer overcomes the bottlenecks of chemotherapy and radiotherapy. Several viruses and their proteins have been evaluated for oncolytic effect. The VP3 protein (apoptin) of chicken anemia virus is one such protein with an inherent ability to lyse cancer and transformed cells while leaving normal cells unharmed. In the present study, the apoptosis inducing potential of VP3 protein of CAV was evaluated in human cervical cancer cell line (HeLa). It was found that in VP3-induced apoptosis, caspase-dependent intrinsic pathway plays an important role with the cleavage of poly (ADP-ribose) polymerase (PARP) and there was no evidence of involvement of death receptor-mediated extrinsic pathway. The results of this study provide intuitive information and strengthen the candidacy of apoptin as a viral oncotherapeutic agent.