Simultaneous Determination of Three Tranquillizers in Lamb Liver by Ultra-Performance Liquid Chromatography–Tandem Mass Spectrometry

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• 作者：Linli Cheng ; Jianzhong Shen ; Qidi Zhang ; Yujie Zhang…
• 关键词：Tranquillizers ; Residue ; UPLC ; MS/MS ; Lamb liver
• 刊名：Food Analytical Methods
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：8
• 期：7
• 页码：1876-1882
• 全文大小：315 KB
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• 作者单位：Linli Cheng (1)
  Jianzhong Shen (1)
  Qidi Zhang (2)
  Yujie Zhang (3)
  Suxia Zhang (1)
  
  1. The National Reference Laboratory for Residue Analysis of Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China
  2. College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Chengyang, Qingdao, 266109, China
  3. China Institute of Veterinary Drugs Control, Beijing, 100081, China
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Food Science
  Chemistry
  Microbiology
  Analytical Chemistry
  
• 出版者：Springer New York
• ISSN：1936-976X

文摘

In animal husbandry, diazepam, chlorpromazine, and promethazine are illegally used to promote growth and increase weight, thus leading to food safety problems. Here, an easy and sensitive method was developed for simultaneous determination of these three drugs in lamb liver. Liver sample was extracted with 25?% ammonium hydroxide–ethyl acetate–chloroform (2:17:2, v/v/v) and cleaned up with an alumina N cartridge. The target compounds were quantified and identified by ultra-performance liquid chromatography (UPLC) coupled with electrospray ionization tandem mass spectrometry (ESI/MS/MS) operated in multiple reaction monitoring mode. At the fortified levels of 0.5-?μg?kg?, recoveries of all drugs in lamb liver were between 94.84?±-.78?% to 99.52?±-1.25?% with 4.48-1.27?% of intra-day coefficient variations (CVs) and 5.72-2.00?% of inter-day CVs. Limit of detection and limit of quantification of the three drugs were 0.05-.16?μg?kg? and 0.15-.50?μg?·?kg?, respectively. The method was demonstrated to be reliable and sensitive.