Effects of diphenyl and p-chloro-diphenyl diselenides on feeding behavior of rats

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• 作者：Cristiani F. Bortolatto ; Suélen O. Heck ; Bibiana M. Gai…
• 关键词：Selenium ; Anorectic ; like action ; Meal pattern ; Satiety ; Serotonin ; Rats
• 刊名：Psychopharmacology
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：232
• 期：13
• 页码：2239-2249
• 全文大小：1,291 KB
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• 作者单位：Cristiani F. Bortolatto (1)
  Suélen O. Heck (1)
  Bibiana M. Gai (1)
  Vanessa A. Zborowski (1)
  José S. S. Neto (1)
  Cristina W. Nogueira (1)
  
  1. Laboratory of Synthesis, Reactivity, Pharmacological and Toxicological Evaluation of Organochalcogen Compounds, Department of Biochemistry and Molecular Biology, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, 97105-900, Brazil
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2072

文摘

Rationale The searching for safe and effective antiobesity drugs has been the subject of intense research. Previous studies have shown several pharmacological applications of organoselenium compounds; however, their possible anorectic-like actions have not been investigated. Objective This study aims to investigate the effects of (PhSe)2 and (p-ClPhSe)2 on feeding behavior of rats and their potential as weight-reducing agents. Methods The effects of intraperitoneal administration of diselenides were investigated through the microstructural pattern of feeding behavior, behavioral satiety sequence (BSS), hypothalamic serotonin (5-HT) uptake, body weight, and epididymal fat content of male rats. Results Our findings demonstrated that food intake of fasted rats was reduced by both diselenides (1 and 10?mg/kg). Diphenyl diselenide [(PhSe)2] (1?mg/kg) and p-chloro-diphenyl diselenide [(p-ClPhSe)2] (10?mg/kg) decreased the frequency, mean duration, and mean size of meals compared with the control treatment. The BSS structure was preserved when organoselenium compounds (1?mg/kg) were administered, and it was associated to a displacement to the left when the resting period started indicating a satiating action. Inhibition of 5-HT uptake in the hypothalamus (?0?%) was also found in rats treated with low doses of (PhSe)2 and (p-ClPhSe)2 (1?mg/kg). Treatments with a high dose of both diselenides (10?mg/kg) carried out for 7?days induced weight loss and epididymal fat reduction in sated rats. Conclusion This study suggests that diselenides caused a satiating action in rats that could be partially explained by the inhibition of hypothalamic 5-HT uptake. These organoselenium compounds were potential weight-reducing agents when repeatedly administered.