DNA vaccine prime and recombinant FPV vaccine boost: an important candidate immunization strategy to control bluetongue virus type 1

详细信息    查看全文

• 作者：Junping Li ; Tao Yang ; Qingyuan Xu ; Encheng Sun&#8230
• 关键词：Bluetongue virus ; DNA vaccine ; rFPV vaccine ; Prime ; boost
• 刊名：Applied Microbiology and Biotechnology
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：99
• 期：20
• 页码：8643-8652
• 全文大小：936 KB
• 参考文献：Belhouchet M, Jaafar FM, Firth AE, Grimes JM, Mertens PPC, Attoui H (2011) Detection of a fourth orbivirus non-structural protein. PloS one 6(10) doi:ARTN e25697 doi: 10.鈥?371/鈥媕ournal.鈥媝one.鈥?025697
  Berhe G, Minet C, Le Goff C, Barrett T, Ngangnou A, Grillet C, Libeau G, Fleming M, Black DN, Diallo A (2003) Development of a dual recombinant vaccine to protect small ruminants against peste-des-petits-ruminants virus and capripoxvirus infections. J Virol 77(2):1571鈥?577PubMed Central CrossRef PubMed
  Bonneau KR, Zhang NZ, Zhu JB, Zhang FQ, Li ZH, Zhang KL, Xiao L, Xiang WB, MacLachlan NJ (1999) Sequence comparison of the L2 and S10 genes of bluetongue viruses from the United States and the People鈥檚 Republic of China. Virus Res 61(2):153鈥?60. doi:10.鈥?016/鈥婼0168-1702(99)00034-9 CrossRef PubMed
  Boone JD, Balasuriya UB, Karaca K, Audonnet JC, Yao J, He L, Nordgren R, Monaco F, Savini G, Gardner IA, Maclachlan NJ (2007) Recombinant canarypox virus vaccine co-expressing genes encoding the VP2 and VP5 outer capsid proteins of bluetongue virus induces high level protection in sheep. Vaccine 25(4):672鈥?78. doi:10.鈥?016/鈥媕.鈥媣accine.鈥?006.鈥?8.鈥?25 CrossRef PubMed
  Calvo-Pinilla E, Castillo-Olivares J, Jabbar T, Ortego J, de la Poza F, Marin-Lopez A (2014) Recombinant vaccines against bluetongue virus. Virus Res 182:78鈥?6. doi:10.鈥?016/鈥媕.鈥媣irusres.鈥?013.鈥?1.鈥?13 CrossRef PubMed
  Calvo-Pinilla E, Navasa N, Anguita J, Ortego J (2012) Multiserotype protection elicited by a combinatorial prime-boost vaccination strategy against bluetongue virus. PLoS One 7(4):e34735. doi:10.鈥?371/鈥媕ournal.鈥媝one.鈥?034735 PubMed Central CrossRef PubMed
  Calvo-Pinilla E, Rodriguez-Calvo T, Sevilla N, Ortego J (2009) Heterologous prime boost vaccination with DNA and recombinant modified vaccinia virus Ankara protects IFNAR(鈭?鈭? mice against lethal bluetongue infection. Vaccine 28(2):437鈥?45. doi:10.鈥?016/鈥媕.鈥媣accine.鈥?009.鈥?0.鈥?27 CrossRef PubMed
  Chen W, Hu S, Qu L, Hu Q, Zhang Q, Zhi H, Huang K, Bu Z (2010) A goat poxvirus-vectored peste-des-petits-ruminants vaccine induces long-lasting neutralization antibody to high levels in goats and sheep. Vaccine 28(30):4742鈥?750. doi:10.鈥?016/鈥媕.鈥媣accine.鈥?010.鈥?4.鈥?02 CrossRef PubMed
  Dungu B, Gerdes T, Smit T (2004a) The use of vaccination in the control of bluetongue in southern Africa. Vet Ital 40(4):616鈥?22PubMed
  Dungu B, Potgieter C, Von Teichman B, Smit T (2004b) Vaccination in the control of bluetongue in endemic regions: the South African experience. Dev Biol 119:463鈥?72
  Ferrari G, De Liberato C, Scavia G, Lorenzetti R, Zini M, Farina F, Magliano A, Cardeti G, Scholl F, Guidoni M, Scicluna MT, Amaddeo D, Scaramozzino P, Autorino GL (2005) Active circulation of bluetongue vaccine virus serotype-2 among unvaccinated cattle in central Italy. Prevent Vet Med 68(2鈥?):103鈥?13. doi:10.鈥?016/鈥媕.鈥媝revetmed.鈥?004.鈥?1.鈥?11 CrossRef
  Franceschi V, Capocefalo A, Calvo-Pinilla E, Redaelli M, Mucignat-Caretta C, Mertens P, Ortego J, Donofrio G (2011) Immunization of knock-out alpha/beta interferon receptor mice against lethal bluetongue infection with a BoHV-4-based vector expressing BTV-8 VP2 antigen. Vaccine 29(16):3074鈥?082. doi:10.鈥?016/鈥媕.鈥媣accine.鈥?011.鈥?1.鈥?75 CrossRef PubMed
  Hamilton MA, Russo RC, Thurston RV (1977) Trimmed Spearman-Karber method for estimating median lethal concentrations in toxicity bioassays. Environ Sci Technol 11(7):714鈥?19CrossRef
  Han Z, Harty RN (2004) The NS3 protein of bluetongue virus exhibits viroporin-like properties. J Biol Chem 279(41):43092鈥?3097. doi:10.鈥?074/鈥媕bc.鈥婱403663200 CrossRef PubMed
  Hassan SH, Wirblich C, Forzan M, Roy P (2001) Expression and functional characterization of bluetongue virus VP5 protein: role in cellular permeabilization. J Virol 75(18):8356鈥?367PubMed Central CrossRef PubMed
  Hofmann MA, Renzullo S, Planzer J, Mader M, Chaignat V, Thuer B (2010) Detection of Toggenburg Orbivirus by a segment 2-specific quantitative RT-PCR. J Virol Methods 165(2):325鈥?29. doi:10.鈥?016/鈥媕.鈥媕viromet.鈥?010.鈥?2.鈥?27 CrossRef PubMed
  Jabbar TK, Calvo-Pinilla E, Mateos F, Gubbins S, Bin-Tarif A, Bachanek-Bankowska K, Alpar O, Ortego J, Takamatsu HH, Mertens PPC, Castillo-Olivares J (2013) Protection of IFNAR (鈭?鈭? mice against bluetongue virus serotype 8, by heterologous (DNA/rMVA) and homologous (rMVA/rMVA) vaccination, expressing outer-capsid protein VP2. PloS one 8(4) doi:ARTN e60574 DOI 10.鈥?371/鈥媕ournal.鈥媝one.鈥?060574
  Jiang Y, Yu K, Zhang H, Zhang P, Li C, Tian G, Li Y, Wang X, Ge J, Bu Z, Chen H (2007) Enhanced protective efficacy of H5 subtype avian influenza DNA vaccine with codon optimized HA gene in a pCAGGS plasmid vector. Antivir Res 75(3):234鈥?41. doi:10.鈥?016/鈥媕.鈥媋ntiviral.鈥?007.鈥?3.鈥?09 CrossRef PubMed
  Kochinger S, Renevey N, Hofmann MA, Zimmer G (2014) Vesicular stomatitis virus replicon expressing the VP2 outer capsid protein of bluetongue virus serotype 8 induces complete protection of sheep against challenge infection. Vet Res 45:64. doi:10.鈥?186/鈥?297-9716-45-64 PubMed Central CrossRef PubMed
  Lobato ZI, Coupar BE, Gray CP, Lunt R, Andrew ME (1997) Antibody responses and protective immunity to recombinant vaccinia virus-expressed bluetongue virus antigens. Vet Immunol Immunopathol 59(3鈥?):293鈥?09CrossRef PubMed
  Ma GG, Eschbaumer M, Said A, Hoffmann B, Beer M, Osterrieder N (2012) An equine herpesvirus type 1 (EHV-1) expressing VP2 and VP5 of serotype 8 bluetongue virus (BTV-8) induces protection in a murine infection model. PloS one 7(4) doi:ARTN e34425 DOI 10.鈥?371/鈥媕ournal.鈥媝one.鈥?034425
  Maan S, Maan NS, Nomikou K, Batten C, Antony F, Belaganahalli MN, Samy AM, Reda AA, Al-Rashid SA, El Batel M, Oura CA, Mertens PP (2011a) Novel bluetongue virus serotype from Kuwait. Emerg Infect Dis 17(5):886鈥?89. doi:10.鈥?201/鈥媏id1705.鈥?01742 PubMed Central CrossRef PubMed
  Maan S, Maan NS, Nomikou K, Veronesi E, Bachanek-Bankowska K, Belaganahalli MN, Attoui H, Mertens PP (2011b) Complete genome characterisation of a novel 26th bluetongue virus serotype from Kuwait. PLoS One 6(10):e26147. doi:10.鈥?371/鈥媕ournal.鈥媝one.鈥?026147 PubMed Central CrossRef PubMed
  Mertens PP, Burroughs JN, Anderson J (1987) Purification and properties of virus particles, infectious subviral particles, and cores of bluetongue virus serotypes 1 and 4. Virology 157(2):375鈥?86CrossRef PubMed
  Niwa H, Yamamura K, Miyazaki J (1991) Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108(2):193鈥?99CrossRef PubMed
  Oura CA, Wood JL, Floyd T, Sanders AJ, Bin-Tarif A, Henstock M, Edwards L, Simmons H, Batten CA (2010) Colostral antibody protection and interference with immunity in lambs born from sheep vaccinated with an inactivated Bluetongue serotype 8 vaccine. Vaccine 28(15):2749鈥?753. doi:10.鈥?016/鈥媕.鈥媣accine.鈥?010.鈥?1.鈥?28 CrossRef PubMed
  Oura CA, Wood JL, Sanders AJ, Bin-Tarif A, Henstock M, Edwards L, Floyd T, Simmons H, Batten CA (2009) Seroconversion, neutralising antibodies and protection in bluetongue serotype 8 vaccinated sheep. Vaccine 27(52):7326鈥?330. doi:10.鈥?016/鈥媕.鈥媣accine.鈥?009.鈥?9.鈥?70 CrossRef PubMed
  Perrin A, Albina E, Breard E, Sailleau C, Prome S, Grillet C, Kwiatek O, Russo P, Thiery R, Zientara S, Cetre-Sossah C (2007) Recombinant capripoxviruses expressing proteins of bluetongue virus: evaluation of immune responses and protection in small ruminants. Vaccine 25(37鈥?8):6774鈥?783. doi:10.鈥?016/鈥媕.鈥媣accine.鈥?007.鈥?6.鈥?52 CrossRef PubMed
  Qiao CL, Yu KZ, Jiang YP, Jia YQ, Tian GB, Liu M, Deng GH, Wang XR, Meng QW, Tang XY (2003) Protection of chickens against highly lethal H5N1 and H7N1 avian influenza viruses with a recombinant fowlpox virus co-expressing H5 haemagglutinin and N1 neuraminidase genes. Avian Pathol : J WVPA 32(1):25鈥?2. doi:10.鈥?080/鈥?307945021000070鈥?88 CrossRef
  Raderschall E, Golub EI, Haaf T (1999) Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage. Proc Natl Acad Sci U S A 96(5):1921鈥?926PubMed Central CrossRef PubMed
  Ratinier M, Caporale M, Golder M, Franzoni G, Allan K, Nunes SF, Armezzani A, Bayoumy A, Rixon F, Shaw A, Palmarini M (2011) Identification and characterization of a novel non-structural protein of bluetongue virus. Plos Pathog 7(12) doi:ARTN e1002477 DOI 10.鈥?371/鈥媕ournal.鈥媝pat.鈥?002477
  Roy P, Marshall JJ, French TJ (1990) Structure of the bluetongue virus genome and its encoded proteins. Curr Top Microbiol Immunol 162:43鈥?7PubMed
  Savini G, Cannas A, Casaccia C, Di Gialleonardo L, Leone A, Patta C, Nicolussi P (2010) Risk factors associated with the occurrence of undesired effects in sheep and goats after field vaccination with modified-live vaccine against bluetongue virus serotypes 2, 4 and 16. Vet Microbiol 146(1鈥?):44鈥?0. doi:10.鈥?016/鈥媕.鈥媣etmic.鈥?010.鈥?4.鈥?20 CrossRef PubMed
  Savini G, Lorusso A, Paladini C, Migliaccio P, Di Gennaro A, Di Provvido A, Scacchia M, Monaco F (2014) Bluetongue serotype 2 and 9 modified live vaccine viruses as causative agents of abortion in livestock: a retrospective analysis in Italy. Transbound Emerg Dis 61(1):69鈥?4. doi:10.鈥?111/鈥婽bed.鈥?2004 CrossRef PubMed
  Savini G, MacLachlan NJ, Sanchez-Vizcaino JM, Zientara S (2008) Vaccines against bluetongue in Europe. Comp Immunol Microbiol Infect Dis 31(2鈥?):101鈥?20. doi:10.鈥?016/鈥媕.鈥媍imid.鈥?007.鈥?7.鈥?06 CrossRef PubMed
  Schwartz-Cornil I, Mertens PP, Contreras V, Hemati B, Pascale F, Breard E, Mellor PS, MacLachlan NJ, Zientara S (2008) Bluetongue virus: virology, pathogenesis and immunity. Vet Res 39(5):46. doi:10.鈥?051/鈥媣etres:鈥?008023 CrossRef PubMed
  Stewart M, Dovas CI, Chatzinasiou E, Athmaram TN, Papanastassopoulou M, Papadopoulos O, Roy P (2012) Protective efficacy of Bluetongue virus-like and subvirus-like particles in sheep: presence of the serotype-specific VP2, independent of its geographic lineage, is essential for protection. Vaccine 30(12):2131鈥?139. doi:10.鈥?016/鈥媕.鈥媣accine.鈥?012.鈥?1.鈥?42 CrossRef PubMed
  Top S, Foucras G, Deplanche M, Rives G, Calvalido J, Comtet L, Bertagnoli S, Meyer G (2012) Myxomavirus as a vector for the immunisation of sheep: protection study against challenge with bluetongue virus. Vaccine 30(9):1609鈥?616. doi:10.鈥?016/鈥媕.鈥媣accine.鈥?011.鈥?2.鈥?08 CrossRef PubMed
  Veronesi E, Darpel KE, Hamblin C, Carpenter S, Takamatsu HH, Anthony SJ, Elliott H, Mertens PPC, Mellor PS (2010) Viraemia and clinical disease in dorset poll sheep following vaccination with live attenuated bluetongue virus vaccines serotypes 16 and 4. Vaccine 28(5):1397鈥?403. doi:10.鈥?016/鈥媕.鈥媣accine.鈥?009.鈥?0.鈥?07 CrossRef PubMed
  Wang YLJ, Jiang Y, Xia J, Pei L, Ran D, Chen H (2009) Construction and identification of a fowlpox virus transfer vector. Chin J Prevent Vet Med 31(7):501鈥?04
  Wei P, Sun EC, Liu NH, Yang T, Xu QY, Zhao J, Qin YL, Feng YF, Li JP, Wang WS, Zhang CY, Wu DL (2013) Identification of a novel bluetongue virus 1-specific B-cell epitope using a monoclonal antibody against the VP2 protein. Arch Virol 158(5):1099鈥?104. doi:10.鈥?007/鈥媠00705-012-1590-6 CrossRef PubMed
  Yang T, Liu N, Xu Q, Sun E, Qin Y, Zhao J, Feng Y, Wu D (2012) Complete genomic sequence of bluetongue virus serotype 1 from China. J Virol 86(2):1288鈥?289. doi:10.鈥?128/鈥婮VI.鈥?6688-11 PubMed Central CrossRef PubMed
  Zhang N, MacLachlan NJ, Bonneau KR, Zhu J, Li Z, Zhang K, Zhang F, Xia L, Xiang W (1999) Identification of seven serotypes of bluetongue virus from the People鈥檚 Republic of China. Vet Rec 145(15):427鈥?29CrossRef PubMed
  Zhang Y, Du X, Li W, Li J, Liu J, Zhu J, Zhang N (2010) Genetic diversity of the S10 RNA segment of field and vaccine strains of bluetongue virus from the P. R. China. R Chin Arch Virol 155(2):281鈥?86. doi:10.鈥?007/鈥媠00705-009-0574-7 CrossRef
  Zhao J, Sun EC, Liu NH, Yang T, Xu QY, Qin YL, Yang YH, Wu DL (2012) Phage display identifies an Eastern equine encephalitis virus glycoprotein E2-specific B cell epitope. Vet Immunol Immunopathol 148(3鈥?):364鈥?68. doi:10.鈥?016/鈥媕.鈥媣etimm.鈥?012.鈥?6.鈥?21 CrossRef PubMed
  
• 作者单位：Junping Li (1)
  Tao Yang (1)
  Qingyuan Xu (1)
  Encheng Sun (1)
  Yufei Feng (1)
  Shuang Lv (1)
  Qin Zhang (1)
  Haixiu Wang (1)
  Donglai Wu (1)
  
  1. The Key Laboratory of Veterinary Public Health, Ministry of Agriculture, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences, Harbin, 150001, China
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Biotechnology
  Microbiology
  Microbial Genetics and Genomics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0614

文摘

Bluetongue virus (BTV) is the causative agent of bluetongue (BT), an important sheep disease that caused great economic loss to the sheep industry. There are 26 BTV serotypes based on the outer protein VP2. However, the serotypes BTV-1 and BTV-16 are the two most prevalent serotypes in China. Vaccination is the most effective method of preventing viral infections. Therefore, the need for an effective vaccine against BTV is urgent. In this study, DNA vaccines and recombinant fowlpox virus (rFPV) vaccines expressing VP2 alone or VP2 in combination with VP5 or co-expressing the VP2 and VP5 proteins of BTV-1 were evaluated in both mice and sheep. Several strategies were tested in mice, including DNA vaccine prime and boost, rFPV vaccine prime and boost, and DNA vaccine prime and rFPV vaccine boost. We then determined the best vaccine strategy in sheep. Our results indicated that a strategy combining a DNA vaccine prime (co-expressing VP2 and VP5) followed by an rFPV vaccine boost (co-expressing VP2 and VP5) induced a high titer of neutralizing antibodies in sheep. Therefore, our data suggest that a DNA vaccine consisting of a pCAG-(VP2+VP5) prime and an rFPV-(VP2+VP5) boost is an important candidate for the design of a novel vaccine against BTV-1. Keywords Bluetongue virus DNA vaccine rFPV vaccine Prime-boost