Antinociceptive and anti-inflammatory effects of myricetin 3-O-β-galactoside isolated from Davilla elliptica: involvement of the nitrergic system

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• 作者：Adolfo de Oliveira Azevedo ; Jussara Júlia Campos…
• 关键词：Myricetin 3 ; O ; β ; galactoside ; Antiedematogenic ; Antinociceptive ; Nitric oxide
• 刊名：Journal of Natural Medicines
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：69
• 期：4
• 页码：487-493
• 全文大小：729 KB
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• 作者单位：Adolfo de Oliveira Azevedo (1)
  Jussara Júlia Campos (2)
  Giovane Galdino de Souza (1)
  Clarice de Carvalho Veloso (1)
  Igor Dimitri Gama Duarte (1)
  Fern?o Castro Braga (2)
  Andrea de Castro Perez (1)
  
  1. Laboratory of Pain and Analgesia, Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Av. Presidente Ant?nio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, 31270-010, Brazil
  2. Department of Pharmaceutical Products, Faculty of Pharmacy, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil
  
• 刊物主题：Pharmacology/Toxicology; Plant Sciences; Complementary & Alternative Medicine; Medicinal Chemistry; Pharmacy;
• 出版者：Springer Japan
• ISSN：1861-0293

文摘

We aimed to study the antinociceptive effects of myricetin 3-O-β-galactoside (Mi), a substance isolated from the hydroalcoholic extract of Davilla elliptica. This study examined male Swiss mice, inducible nitric oxide synthase C57B16/J knockout mice (iNOS??/sup>), and their corresponding wild type (WT). Formalin and tail-flick tests were used to evaluate the nociceptive threshold, and the carrageenan-induced paw edema test was used as a model for inflammation. The following drugs were administered to investigate the involvement of the nitrergic and opioidergic systems: l-NAME, a nonspecific nitric oxide synthase (NOS) inhibitor; l-arginine (l-Arg), a precursor for the synthesis of nitric oxide (NO); d-arginine (d-Arg), an inactive isomer for the synthesis of NO; aminoguanidine (Am), an inducible nitric oxide synthase (iNOS) inhibitor; and naloxone, a nonselective antagonist of opioid receptors. The results showed that oral pretreatment with Mi caused a dose-dependent inhibition of the inflammatory phase of the formalin test and did not alter motor performance. Intraperitoneal injection of l-NAME caused a reduction in the licking time during the second phase of the formalin test. The administration of l-Arg (but not d-Arg) reversed the antinociceptive effect of l-NAME. Furthermore, pre-administration of aminoguanidine potentiated the antinociceptive effect. Mi did not cause an antinociceptive effect in iNOS knockouts and led to a reduction in the nitrite concentration in the paws of mice. Carrageenan-induced paw edema was reduced in Swiss mice and WT mice when compared to iNOS??/sup> mice. Pre-administration of naloxone (NLX) did not reverse the antinociceptive effect of Mi, excluding the opioidergic system as a mediator of the antinociceptive effect. Thus, the results suggest that the antinociceptive and anti-inflammatory effects of myricetin 3-O-β-galactoside are related to peripheral inhibition of nitric oxide synthesis, mainly iNOS. Keywords Myricetin 3-O-β-galactoside Antiedematogenic Antinociceptive Nitric oxide