Down-regulation of miR-489 contributes into NSCLC cell invasion through targeting SUZ12

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• 作者：Zongtao Xie ; Liming Cai ; Runsheng Li ; Jinyu Zheng ; Hongyan Wu ; Xiaoqi Yang…
• 关键词：miR ; 489 ; SUZ12 ; Invasion ; EMT ; NSCLC
• 刊名：Tumor Biology
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：36
• 期：8
• 页码：6497-6505
• 全文大小：3,099 KB
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• 作者单位：Zongtao Xie (1)
  Liming Cai (2)
  Runsheng Li (2)
  Jinyu Zheng (3)
  Hongyan Wu (3)
  Xiaoqi Yang (4)
  Hu Li (5)
  Zhiqiang Wang (1)
  
  1. Department of Thoracic and Cardiovascular Surgery, Affiliated Hospital of Jiangnan University, The Forth People鈥檚 Hospital of Wuxi City, No. 200, Huihe Road, Wuxi, 214062, China
  2. Department of Respiratory Medicine, Affiliated Hospital of Jiangnan University, The Forth People鈥檚 Hospital of Wuxi City, No. 200, Huihe Road, Wuxi, 214062, China
  3. Department of Pathology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, No. 321, Zhongshan Road, Nanjing, 210008, China
  4. Department of Orthopedics, Affiliated Hospital of Jiangnan University, The Forth People鈥檚 Hospital of Wuxi City, No. 200, Huihe Road, Wuxi, 214062, China
  5. Department of Plastic Surgery, Affiliated Hospital of Jiangnan University, The Forth People鈥檚 Hospital of Wuxi City, No. 200, Huihe Road, Wuxi, 214062, China
  
• 刊物主题：Cancer Research;
• 出版者：Springer Netherlands
• ISSN：1423-0380

文摘

microRNAs are small, non-coding RNAs that contribute into various biological processes during cancer progression. However, the potential role of miR-489 in the development of Non-Small Cell Lung Cancer (NSCLC) is not demonstrated. In present study, miR-489 was down-regulated both in tumor tissues and cells. Inhibition of miR-489 promoted cells invasion by using an invasion assay. Furthermore, miR-489 could regulate SUZ12 as shown by luciferase reporter and Western blot assays. Aberrant miR-489 expression could regulate the molecular changes (E-cadherin, N-cadherin, and Vimentin) of epithelial mesenchymal transition (EMT). In conclusion, our study revealed that miR-489 may play an essential role in the progression of NSCLC. Keywords miR-489 SUZ12 Invasion EMT NSCLC