Prognostic Risk Factors Associated with Recurrence and Metastasis After Radical Resection in Patients with Hepatolithiasis Complicated by Intrahepatic Cholangiocarcinoma

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• 作者：Yufei Zhu ; Yunhai Zhu ; Feng Cai ; Jie Zhao ; Feng Liu
• 关键词：Hepatolithiasis ; Intrahepatic cholangiocarcinoma ; Radical resection ; Recurrence and metastasis ; Prognostic factors
• 刊名：Cell Biochemistry and Biophysics
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：73
• 期：2
• 页码：455-460
• 全文大小：406 KB
• 参考文献：1.Uenishi, T., Kubo, S., Yamazaki, O., Yamada, T., Sasaki, Y., Nagano, H., & Monden, M. (2008). Indications for surgical treatment of intrahepatic cholangiocarcinoma with lymph node metastases. Journal of Hepatobiliary Pancreatic Surgery, 15(4), 417-22.CrossRef PubMed
  2.Tan, J., Tan, Y., Chen, F., Zhu, Y., Leng, J., & Dong, J. (2015). Endoscopic or laparoscopic approach for hepatolithiasis in the era of endoscopy in China. Surgical Endoscopy, 29(1), 154-62. doi:10.-007/?s00464-014-3669-5 .CrossRef PubMed
  3.Kasai, K., Kooka, Y., Suzuki, Y., Suzuki, A., Oikawa, T., Ushio, A., et al. (2014). Efficacy of hepatic arterial infusion chemotherapy using 5-fluorouracil and systemic pegylated interferon alpha-2b for advanced intrahepatic cholangiocarcinoma. Annals of Surgical Oncology, 21(11), 3638-645.CrossRef PubMed
  4.Yang, X. Q., Xu, Y. F., Guo, S., Liu, Y., Ning, S. L., Lu, X. F., et al. (2014). Clinical significance of nerve growth factor and tropomyosin-receptor-kinase signaling pathway in intrahepatic cholangiocarcinoma. World Journal of Gastroenterology : WJG, 20(14), 4076-084.PubMed Central CrossRef PubMed
  5.Mavros, M. N., Economopoulos, K. P., Alexiou, V. G., & Pawlik, T. M. (2014). Treatment and prognosis for patients with intrahepatic cholangiocarcinoma: Systematic review and meta-analysis. JAMA Surgery. doi:10.-001/?jamasurg.-013.-137 .PubMed
  6.Chen, M. F., Jan, Y. Y., Hwang, T. L., Jeng, L. B., & Yeh, T. S. (2000). Impact of concomitant hepatolithiasis on patients with peripheral cholangiocarcinoma. Digestive Disease Science, 45, 312-16.CrossRef
  7.Zhou, Y. M., Yin, Z. F., Yang, J. M., et al. (2008). Risk factors for intrahepatic cholangiocarcinoma: A case-control study in China. World Journal of Gastroenterology, 14, 632-35.PubMed Central CrossRef PubMed
  8.Kuroki, T., Tajima, Y., & Kanematsu, T. (2005). Hepatolithiasis and intrahepatic cholangiocarcinoma: Carcinogenesis based on molecular mechanisms. Journal of Hepatobiliary and Pancreatic Surgery, 12, 463-66.CrossRef
  9.Lazaridis, K. N., & Gores, G. J. (2005). Cholangiocarcinoma. Gastroenterology, 128, 1655-667.CrossRef PubMed
  10.Tischoff, I., & Tannapfel, A. (2007). Hepatocellular carcinoma and cholangiocarcinoma-different prognosis, pathogenesis and therapy. Zentralblatt für Chirurgie, 2007(132), 300-05.CrossRef
  11.Nakayama, T., Tsuchikawa, T., Shichinohe, T., Nakamura, T., Ebihara, Y., & Hirano, S. (2014). Pathological confirmation of para-aortic lymph node status as a potential criterion for the selection of intrahepatic cholangiocarcinoma patients for radical resection with regional lymph node dissection. World Journal of Surgery, 38(7), 1763-768.CrossRef PubMed
  12.Peycru, T., Hardwigsen, J., Gregoire, E., Barbier, L., Richa, H., Campan, P., & Le Treut, Y. P. (2009). Radical surgery in intrahepatic cholangiocarcinoma. Gastroenterologie Clinique et Biologique, 33(3), 187-93.CrossRef PubMed
  13.Zhang, G. W., Lin, J. H., Qian, J. P., & Zhou, J. (2014). Identification of prognostic factors and the impact of palliative resection on survival of patients with stage IV hepatolithiasis-associated intrahepatic cholangiocarcinoma. Journal of Surgical Oncology, 109(5), 494-99.CrossRef PubMed
  14.Jiang, K., Su, M., Zhang, W., Zhao, X., Wang, J., Dong, J., & Huang, Z. (2014). Complete radiofrequency ablation of hepatolithiasis-associated cholangiocarcinoma and successful management of post-ablation bronchobiliary fistula. Cell Biochemistry and Biophysics, 68(3), 555-59.CrossRef PubMed
  15.Zhu, Q. D., Zhou, M. T., Zhou, Q. Q., Shi, H. Q., Zhang, Q. Y., & Yu, Z. P. (2014). Diagnosis and surgical treatment of intrahepatic hepatolithiasis combined with cholangiocarcinoma. World Journal of Surgery, 38(8), 2097-104.CrossRef PubMed
  16.Jiang, Z. J., Chen, Y., Wang, W. L., Shen, Y., Zhang, M., Xie, H. Y., et al. (2013). Management hepatolithiasis with operative choledochoscopic FREDDY laser lithotripsy combined with or without hepatectomy. Hepatobiliary & Pancreatic Diseases International, 12(2), 160-64.CrossRef
  17.Han, S. L., Zhou, H. Z., Cheng, J., et al. (2009). Diagnosis and surgical treatment of intrahepatic hepatolithiasis associated cholangiocarcinoma. Asian Journal of Surgery, 32(1), 1-.CrossRef PubMed
  18.Edge, S. B., & Compton, C. C. (2010). The American Joint Committee on Cancer: The 7th edition of the AJCC cancer staging manual and the future of TNM. Annals of Surgical Oncology, 17, 1471-474.CrossRef PubMed
  19.Lin, C. C., Lin, P. Y., & Chen, Y. L. (2013). Comparison of concomitant and subsequent cholangiocarcinomas associated with hepatolithiasis: Clinical implications. World Journal of Gastroenterology, 19(3), 375-80.PubMed Central CrossRef PubMed
  20.Yang, T., Lau, W. Y., Lai, E. C., Yang, L. Q., Zhang, J., Yang, G. S., et al. (2010). Hepatectomy for bilateral primary hepatolithiasis: A cohort study. Annals of Surgery, 251(1), 84-0.CrossRef PubMed
  21.Takaoka, M.
• 作者单位：Yufei Zhu (1)
  Yunhai Zhu (1)
  Feng Cai (1)
  Jie Zhao (1)
  Feng Liu (2)
  
  1. Department of Liver & Gallbladder Surgery, The First People’s Hospital, Shangqiu, Henan, China
  2. Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Jimo Road 150, Shanghai, 200120, China
  
• 刊物主题：Biochemistry, general; Pharmacology/Toxicology; Biotechnology; Cell Biology; Biophysics and Biological Physics;
• 出版者：Springer US
• ISSN：1559-0283

文摘

The objective of this study was to analyze the predictive significance of different prognostic factors associated with recurrence and metastasis after the radical resection in patients with hepatolithiasis complicated by intrahepatic cholangiocarcinoma (HLA/IHCC). A total of 138 patients with HLA/IHCC admitted during April 2006–April 2009 were selected for this study and they were divided into two groups, with and without recurrence/metastasis. After a radical resection surgery, the patients were followed up for 5 years to monitor the recurrence and/or metastasis. The general and clinical data of the two groups were analyzed to evaluate the relevant risk factors. The study showed that recurrence/metastasis occurred in 48 patients with a rate of 34.8 %. Recurrence in liver accounted for 85.4 % (41 cases), whereas in lung and bone metastases occurred at rates of 8.3 % (4 cases) and 6.3 % (3 cases), respectively. Univariate analysis revealed that CA19-9, tumor diameter, tumor amount, lymphatic metastasis, and AJCC stage of the recurrence/metastasis group were significantly different from those of the non-recurrence/metastasis patients (p < 0.05). The multivariate analysis showed that CA19-9 > 200 U/mL, tumor diameter >5 cm, presence of multiple tumors, lymphatic metastasis, and III–IV AJCC stages were independent risk factors of tumor recurrence and metastasis after the radical surgery (p < 0.05). During the 5 years of follow-up, 65 patients (47.1 %) died, including 31 in the recurrence/metastasis and 34 in the non-recurrence/metastasis groups, accounting for 64.5 % (31/48) and 37.8 % (34/90) of mortality in the two groups, respectively. Thus, the 5-year mortality in the recurrence/metastasis group was significantly higher than that in the non-recurrence/metastasis group (p < 0.05). The CA19-9 antigen, tumor diameter, tumor amount, lymphatic metastasis, and AJCC stage were significantly associated with increased risk of post-resection recurrence and metastasis of HLA/IHCC. The massive lymphadenectomy during the surgery and perioperative control of inflammation decreased the risk of recurrence/metastasis and further improved the disease prognosis. Keywords Hepatolithiasis Intrahepatic cholangiocarcinoma Radical resection Recurrence and metastasis Prognostic factors