Neurotoxicity of acrylonitrile evaluated by manganese enhanced magnetic resonance imaging

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• 作者：Ying Li ; Lihong Mei ; Jinwei Qiang ; Chi-Shing Zee…
• 关键词：Acrylonitrile ; Brain lesions ; Oxidative damage ; Pollutant ; Non ; invasive method ; Manganeseenhanced magnetic resonance imaging
• 刊名：Molecular & Cellular Toxicology
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：11
• 期：3
• 页码：367-372
• 全文大小：936 KB
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• 作者单位：Ying Li (1)
  Lihong Mei (2)
  Jinwei Qiang (1)
  Chi-Shing Zee (3)
  Xiuju Li (4)
  Junhua Liu (5)
  
  1. Department of Radiology, Jinshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
  2. Department of Dermatology, Jinshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
  3. Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, USA
  4. Department of Occupation Disease Prevention, Jinshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
  5. Department of Radiology, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China
  
• 刊物主题：Cell Biology; Pharmacology/Toxicology;
• 出版者：Springer Netherlands
• ISSN：2092-8467

文摘

Acrylonitrile (ACN), a chemical compound commonly used to manufacture plastics, has been found in drin king water and as a pollutant in the air. Exposure to high levels of ACN leads to brain lesions via oxidative stress-induced injury. To date, there is no non-invasive method of examining brain lesions. We determined if manganese-enhanced magnetic resonance imaging (MEMRI) can be used to detect brain lesions in ACN-treated rats by exploiting the binding properties of manganese to the enzymes manganesesuperoxide dismutase (Mn-SOD) and glutamine synthetase (GS). Rats exposed to low, mid, and high doses of ACN over 7 days were subjected to MEMRI on the eighth day. Contrast enhancement of the brain decreased in ACN-treated rats, along with marked decreases in Mn-SoD and GS activities, particularly in mid- and high-ACN treated rats. Our study indicates that MEM-RI may be a potential non-invasive method of detecting ACN-induced oxidative damage. Keywords Acrylonitrile Brain lesions Oxidative damage Pollutant Non-invasive method Manganeseenhanced magnetic resonance imaging