Rhizopus arrhizus and Fusarium solani Concomitant Infection in an Immunocompromised Host

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• 作者：Jo茫o N. de Almeida J煤nior ; Karim Y. Ibrahim ; Gilda M. B. Del Negro…
• 关键词：Rhizopus arrhizus ; Fusarium solani ; Neutropenia ; PCR methods ; Paraffin ; embedded tissue section
• 刊名：Mycopathologia
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：181
• 期：1-2
• 页码：125-129
• 全文大小：702 KB
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• 作者单位：Jo茫o N. de Almeida J煤nior (1) (2)
  Karim Y. Ibrahim (3)
  Gilda M. B. Del Negro (1)
  Evandro D. Bezerra (4)
  Amaro N. Duarte Neto (5)
  Marjorie V. Batista (6)
  Rinaldo F. Siciliano (7)
  Mauro C. Giudice (1)
  Adriana L. Motta (2)
  Fl谩via Rossi (2)
  Ligia C. Pierrotti (3)
  Maristela P. Freire (3)
  Marcelo Bellesso (4)
  Juliana Pereira (4)
  Edson Abdala (3) (6)
  Gil Benard (1)
  
  1. Laboratory of Medical Mycology (LIM-53), Division of Dermatology Clinic, Hospital das Cl铆nicas da FMUSP and Instituto de Medicina Tropical de S茫o Paulo, Universidade de S茫o Paulo, S茫o Paulo, Brazil
  2. Central Laboratory Division (LIM-03), Hospital das Cl铆nicas da Faculdade de Medicina da Universidade de S茫o Paulo, Av. Dr. En茅as de Carvalho Aguiar, 255 - Cerqueira C茅sar, S茫o Paulo, 05403-000, Brazil
  3. Infection Control Division, Instituto do C芒ncer do Estado de S茫o Paulo, Hospital das Cl铆nicas da Faculdade de Medicina da Universidade de S茫o Paulo, S茫o Paulo, Brazil
  4. Hemathology Department, Hospital das Cl铆nicas da Faculdade de Medicina da Universidade de S茫o Paulo, S茫o Paulo, Brazil
  5. Pathology Department, Hospital das Cl铆nicas da Faculdade de Medicina da Universidade de S茫o Paulo, S茫o Paulo, Brazil
  6. Infectious Diseases Division, Hospital das Cl铆nicas da Faculdade de Medicina da Universidade de S茫o Paulo, S茫o Paulo, Brazil
  7. Cardiology Institute, Hospital das Cl铆nicas da Faculdade de Medicina da Universidade de S茫o Paulo, S茫o Paulo, Brazil
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Microbiology
  Medical Microbiology
  Plant Sciences
  Microbial Ecology
  
• 出版者：Springer Netherlands
• ISSN：1573-0832

文摘

Neutropenic patients are at risk of the development of hyalohyphomycosis and mucormycosis. Correct identification is essential for the initiation of the specific treatment, but concomitant mold infections are rarely reported. We report one unprecedented case of concomitant mucormycosis and fusariosis in a neutropenic patient with acute myeloid leukemia. The patient developed rhino-orbital infection by Rhizopus arrhizus and disseminated infection by Fusarium solani. The first culture from a sinus biopsy grew Rhizopus, which was consistent with the histopathology report of mucormycosis. A second sinus biopsy collected later during the patient鈥檚 clinical deterioration was reported as hyalohyphomycosis, and the culture yielded F. solani. Due to the discordant reports, the second biopsy was reviewed and two hyphae types suggestive of both hyalohyphomycetes and mucormycetes were found. The dual mold infection was confirmed by PCR assays from paraffinized tissue sections. Increased awareness of the existence of dual mold infections in at-risk patients is necessary. PCR methods in tissue sections may increase the diagnosis of dual mold infections. In case of sequential biopsies showing discrepant results, mixed infections have to be suspected. Keywords Rhizopus arrhizus Fusarium solani Neutropenia PCR methods Paraffin-embedded tissue section