Rapid and Effective Virucidal Activity of Povidone-Iodine Products Against Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and Modified Vaccinia Virus Ankara (MVA)

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• 作者：Maren Eggers ; Markus Eickmann ; Juergen Zorn
• 关键词：Enveloped virus ; Gargle ; Hand hygiene ; MERS ; CoV ; Middle East respiratory syndrome coronavirus ; Modified vaccinia virus Ankara ; Mouthwash ; MVA ; Povidone iodine ; Virucidal
• 刊名：Infectious Diseases and Therapy
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：4
• 期：4
• 页码：491-501
• 全文大小：470 KB
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• 作者单位：Maren Eggers (1)
  Markus Eickmann (2)
  Juergen Zorn (3)
  
  1. Labor Prof. Gisela Enders MVZ GbR and the Institute of Virology, Infectious Diseases and Epidemiology e.V., Stuttgart, Germany
  2. Institute for Virology, Philipps University of Marburg, Marburg, Germany
  3. Mundipharma Research GmbH & Co.KG, Limburg, Germany
  
• 刊物主题：Internal Medicine; Infectious Diseases;
• 出版者：Springer Healthcare
• ISSN：2193-6382

文摘

Introduction Since the first case of Middle East Respiratory Syndrome coronavirus (MERS-CoV) infection was reported in 2012, the virus has infected more than 1300 individuals in 26 countries, and caused more than 480 deaths. Human-to-human transmission requires close contact, and has typically occurred in the healthcare setting. Improved global awareness, together with improved hygiene practices in healthcare facilities, has been highlighted as key strategies in controlling the spread of MERS-CoV. This study tested the in vitro efficacy of three formulations of povidone iodine (PVP-I: 4% PVP-I skin cleanser, 7.5% PVP-I surgical scrub, and 1% PVP-I gargle/mouthwash) against a reference virus (Modified vaccinia virus Ankara, MVA) and MERS-CoV.