Chronic intermittent hypoxia leads to insulin resistance and impaired glucose tolerance through dysregulation of adipokines in non-obese rats

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• 作者：Cuiping Fu ; Liyan Jiang ; Fen Zhu ; Zilong Liu ; Wenjing Li ; Hong Jiang…
• 关键词：Sleep apnea ; Chronic intermittent hypoxia ; Insulin resistance ; Impaired glucose tolerance ; Adipokine
• 刊名：Sleep and Breathing
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：19
• 期：4
• 页码：1467-1473
• 全文大小：507 KB
• 参考文献：1.Ip MS, Lam B, Ng MM, Lam WK, Tsang KW, Lam KS (2002) Obstructive sleep apnea is independently associated with insulin resistance. Am J Respir Crit Care Med 165(5):670鈥?76. doi:10.鈥?164/鈥媋jrccm.鈥?65.鈥?.鈥?103001 CrossRef PubMed
  2.Robinson GV, Stradling JR, Davies RJ (2004) Sleep. 6: obstructive sleep apnoea/hypopnoea syndrome and hypertension. Thorax 59(12):1089鈥?094. doi:10.鈥?136/鈥媡hx.鈥?003.鈥?15875 PubMedCentral CrossRef PubMed
  3.Vatansever E, Surmen-Gur E, Ursavas A, Karadag M (2011) Obstructive sleep apnea causes oxidative damage to plasma lipids and proteins and decreases adiponectin levels. Sleep Breath 15(3):275鈥?82. doi:10.鈥?007/鈥媠11325-010-0378-8 CrossRef PubMed
  4.Iiyori N, Alonso LC, Li J, Sanders MH, Garcia-Ocana A, O'Doherty RM, Polotsky VY, O'Donnell CP (2007) Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity. Am J Respir Crit Care Med 175(8):851鈥?57. doi:10.鈥?164/鈥媟ccm.鈥?00610-1527OC PubMedCentral CrossRef PubMed
  5.Muraki I, Tanigawa T, Yamagishi K, Sakurai S, Ohira T, Imano H, Kitamura A, Kiyama M, Sato S, Shimamoto T, Konishi M, Iso H (2010) Nocturnal intermittent hypoxia and the development of type 2 diabetes: the Circulatory Risk in Communities Study (CIRCS). Diabetologia 53(3):481鈥?88. doi:10.鈥?007/鈥媠00125-009-1616-0 CrossRef PubMed
  6.Ailhaud G (2006) Adipose tissue as a secretory organ: from adipogenesis to the metabolic syndrome. C R Biol 329 (8):570-577, 653-655. doi:10.鈥?016/鈥媕.鈥媍rvi.鈥?005.鈥?2.鈥?12
  7.Al MS, Mojiminiyi OA, Al AA, Al RT, Abdella N (2014) Study of leptin and adiponectin as disease markers in subjects with obstructive sleep apnea. Dis Markers 2014:706314. doi:10.鈥?155/鈥?014/鈥?06314
  8.Diogo LN, Monteiro EC (2014) The efficacy of antihypertensive drugs in chronic intermittent hypoxia conditions. Front Physiol 5:361. doi:10.鈥?389/鈥媐phys.鈥?014.鈥?0361 PubMedCentral CrossRef PubMed
  9.Wang X, Liang L, Junfen FU, Lizhong DU (2007) Metabolic syndrome in obese children born large for gestational age. Indian J Pediatr 74(6):561鈥?65CrossRef PubMed
  10.Ben Y, Chen J, Zhu R, Gao L, Bai C (2008) Upregulation of AQP3 and AQP5 induced by dexamethasone and ambroxol in A549 cells. Respir Physiol Neurobiol 161(2):111鈥?18. doi:10.鈥?016/鈥媕.鈥媟esp.鈥?007.鈥?2.鈥?07 CrossRef PubMed
  11.Chen L, Cao ZL, Han F, Gao ZC, He QY (2010) Chronic intermittent hypoxia from pedo-stage decreases glucose transporter 4 expression in adipose tissue and causes insulin resistance. Chin Med J (Engl) 123(4):463鈥?70
  12.Matsuzawa Y, Funahashi T, Nakamura T (1999) Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances. Ann N Y Acad Sci 892:146鈥?54CrossRef PubMed
  13.Varady KA, Tussing L, Bhutani S, Braunschweig CL (2009) Degree of weight loss required to improve adipokine concentrations and decrease fat cell size in severely obese women. Metabolism 58(8):1096鈥?101. doi:10.鈥?016/鈥媕.鈥媘etabol.鈥?009.鈥?4.鈥?10 CrossRef PubMed
  14.Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Et A (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334(5):292鈥?95. doi:10.鈥?056/鈥婲EJM199602013340鈥?03 CrossRef PubMed
  15.Vidal H, Auboeuf D, De Vos P, Staels B, Riou JP, Auwerx J, Laville M (1996) The expression of ob gene is not acutely regulated by insulin and fasting in human abdominal subcutaneous adipose tissue. J Clin Invest 98(2):251鈥?55. doi:10.鈥?172/鈥婮CI118786 PubMedCentral CrossRef PubMed
  16.Vazquez-Vela ME, Torres N, Tovar AR (2008) White adipose tissue as endocrine organ and its role in obesity. Arch Med Res 39(8):715鈥?28. doi:10.鈥?016/鈥媕.鈥媋rcmed.鈥?008.鈥?9.鈥?05 CrossRef PubMed
  17.Jain SH, Massaro JM, Hoffmann U, Rosito GA, Vasan RS, Raji A, O'Donnell CJ, Meigs JB, Fox CS (2009) Cross-sectional associations between abdominal and thoracic adipose tissue compartments and adiponectin and resistin in the Framingham Heart Study. Diabetes Care 32:903鈥?08PubMedCentral CrossRef PubMed
  18.Azuma K, Katsukawa F, Oguchi S, Murata M, Yamazaki H, Shimada A, Saruta T (2003) Correlation between serum resistin level and adiposity in obese individuals. Obes Res 11(8):997鈥?001. doi:10.鈥?038/鈥媜by.鈥?003.鈥?37 CrossRef PubMed
  19.Vong L, Ye C, Yang Z, Choi B, Chua SJ, Lowell BB (2011) Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron 71(1):142鈥?54. doi:10.鈥?016/鈥媕.鈥媙euron.鈥?011.鈥?5.鈥?28 PubMedCentral CrossRef PubMed
  20.Menzaghi C, Ercolino T, Di Paola R, Berg AH, Warram JH, Scherer PE, Trischitta V, Doria A (2002) A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome. Diabetes 51(7):2306鈥?312CrossRef PubMed
  21.Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, Et A (1995) Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1(11):1155鈥?161CrossRef PubMed
  22.Yu JG, Javorschi S, Hevener AL, Kruszynska YT, Norman RA, Sinha M, Olefsky JM (2002) The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. Diabetes 51(10):2968鈥?974CrossRef PubMed
  23.Wang B, Wood IS, Trayhurn P (2007) Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes. Pflugers Arch 455(3):479鈥?92. doi:10.鈥?007/鈥媠00424-007-0301-8 PubMedCentral CrossRef PubMed
  24.Ye J, Gao Z, Yin J, He Q (2007) Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab 293(4):E1118鈥揈1128. doi:10.鈥?152/鈥媋jpendo.鈥?0435.鈥?007 CrossRef PubMed
  25.Chen B, Lam KS, Wang Y, Wu D, Lam MC, Shen J, Wong L, Hoo RL, Zhang J, Xu A (2006) Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes. Biochem Biophys Res Commun 341(2):549鈥?56. doi:10.鈥?016/鈥媕.鈥媌brc.鈥?006.鈥?1.鈥?04 CrossRef PubMed
  26.Wiesner G, Brown RE, Robertson GS, Imran SA, Ur E, Wilkinson M (2006) Increased expression of the adipokine genes resistin and fasting-induced adipose factor in hypoxic/ischaemic mouse brain. Neuroreport 17(11):1195鈥?198. doi:10.鈥?097/鈥?1.鈥媤nr.鈥?000224776.鈥?2647.鈥媌a CrossRef PubMed
  27.Wang B, Wood IS, Trayhurn P (2008) Hypoxia induces leptin gene expression and secretion in human preadipocytes: differential effects of hypoxia on adipokine expression by preadipocytes. J Endocrinol 198(1):127鈥?34. doi:10.鈥?677/鈥婮OE-08-0156 CrossRef PubMed
  28.Bedessem B, Stephanou A (2014) Role of compartmentalization on HiF-1alpha degradation dynamics during changing oxygen conditions: a computational approach. PLoS One 9(10):e110495. doi:10.鈥?371/鈥媕ournal.鈥媝one.鈥?110495 PubMedCentral CrossRef PubMed
  29.Semenza G (2002) Signal transduction to hypoxia-inducible factor 1. Biochem Pharmacol 64(5鈥?):993鈥?98CrossRef PubMed
  
• 作者单位：Cuiping Fu (1)
  Liyan Jiang (2)
  Fen Zhu (1)
  Zilong Liu (1)
  Wenjing Li (1)
  Hong Jiang (1)
  Hongying Ye (3)
  Clete A. Kushida (4)
  Shanqun Li (1) (5)
  
  1. Department of Respiratory Medicine, Clinical Center for Sleep Breathing Disorder and Snoring, Zhongshan Hospital, Fudan University, Shanghai, China
  2. Department of Respiratory Medicine, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China
  3. Division of Endocrinology, Hua Shan Hospital, Fudan University, Shanghai, China
  4. Stanford University Sleep Clinic and Center for Human Sleep Research, Redwood City, CA, USA
  5. Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Fenglin Road 180, Xuhui District, Shanghai, 200032, People鈥檚 Republic of China
  
• 刊物主题：Pneumology/Respiratory System; Otorhinolaryngology; Dentistry; Neurology; Internal Medicine; Pediatrics;
• 出版者：Springer Berlin Heidelberg
• ISSN：1522-1709

文摘

Background and objectives The aim of this study was to determine whether chronic intermittent hypoxia (CIH) could affect the secretion of adipokines, such as resistin, leptin, and adiponectin, in non-obese rats and to investigate the potential mechanisms.