Diazoxide protects L6 skeletal myoblasts from H2O2-induced apoptosis via the phosphatidylinositol-3 kinase/Akt pathway

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• 作者：Wei Chen ; Yan Liu ; Guoyu Xue ; Lisi Zhang ; Lei Zhang ; Suxia Shao
• 关键词：Skeletal myoblast ; Apoptosis ; Diazoxide ; Phosphatidylinositol ; 3 kinase/Akt pathway ; Apoptotic signalling pathway
• 刊名：Inflammation Research
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：65
• 期：1
• 页码：53-60
• 全文大小：1,398 KB
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• 作者单位：Wei Chen (1)
  Yan Liu (2)
  Guoyu Xue (1)
  Lisi Zhang (1)
  Lei Zhang (1)
  Suxia Shao (1)
  
  1. Department of Histology and Embryology, Basic Medical College, Hebei Medical University, Zhongshan East Road 361, Shijiazhuang City, 050017, Hebei Province, People’s Republic of China
  2. Department of Endocrinology, The 3rd Hospital of Hebei Medical University, Ziqiang Road 139, Shijiazhuang City, Hebei Province, People’s Republic of China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Immunology
  Pharmacology and Toxicology
  Allergology
  Dermatology
  Neurology
  Rheumatology
  
• 出版者：Birkh盲user Basel
• ISSN：1420-908X

文摘

Objectives and design Transplanted cell survival might greatly improve the therapeutic efficacy of cell therapy. Diazoxide (DZ), a highly selective mitochondrial ATP-sensitive potassium channel opener, is known to suppress cell apoptosis and protect cells in oxidative stressed ischemic environment. We explored the mechanisms involved in DZ pre-treatment-induced anti-apoptotic effect on L6 skeletal myoblast (SKM).