Self-assembly of Novel Poly(d,l-Lactide-co-Glycolide)-b-Poly(N-Vinylpyrrolidone) (PLGA-b-PNVP) Amphiphilic Diblock Copolymers

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• 作者：K. Ramesh ; Shikha Singh ; Kheyanath Mitra…
• 关键词：PLGA ; b ; PNVP ; RAFT ; Alkyne ; azide click reaction
• 刊名：Colloid & Polymer Science
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：294
• 期：2
• 页码：399-407
• 全文大小：1,700 KB
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• 作者单位：K. Ramesh (1) (2)
  Shikha Singh (1)
  Kheyanath Mitra (1)
  Dipankar Chattopadhyay (3)
  Nira Misra (2)
  Biswajit Ray (1)
  
  1. Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi, 221005, India
  2. School of Biomedical Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India
  3. Department of Polymer Science and Technology, University of Calcutta, 92, A. P. C. Road, Kolkata, 700 009, India
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Polymer Sciences
  Physical Chemistry
  Soft Matter and Complex Fluids
  Characterization and Evaluation Materials
  Food Science
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1435-1536

文摘

Alkyne-terminated poly(d,l-lactide-co-glycolide) (PLGA) has been synthesized via ROP at room temperature. Amphiphilic PLGA-b-poly(N-vinylpyrrolidone) (PNVP) block copolymers have been synthesized via alkyne-azide click reaction of it with azide-terminated PNVPs prepared by RAFT polymerization of NVP using an azide-terminated RAFT agent. 1H NMR and gel permeation chromatography (GPC) confirmed the formation of block copolymers. Self-assembly of these block copolymers was confirmed by fluorescence study using pyrene as a probe and supported by 1H NMR, DLS and TEM studies. Hydrophobic drug doxorubicin was successfully encapsulated at the micellar core of PLGA₄₆-b-PNVP₈₉ with drug-loading content (DLC) and drug-loading efficiency (DLE) of 10.8 and 43.2 %, respectively. Sustained drug release of these drug-loaded micelles was observed at both pH of 6.4 and 7.4. Faster drug release was observed at pH 6.4. Such PLGA-b-PNVP amphiphilic block copolymer may find extensive application in sustained drug delivery, specifically in antitumor drug delivery. Keywords PLGA-b-PNVP RAFT Alkyne-azide click reaction