Reorganization of a synthetic microbial consortium for one-step vitamin C fermentation
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- 作者：En-Xu Wang ; Ming-Zhu Ding ; Qian Ma ; Xiu-Tao Dong ; Ying-Jin Yuan
- 关键词：Synthetic microbial consortium ; Reorganization ; One ; step fermentation ; Interaction ; Metabolomics
- 刊名：Microbial Cell Factories
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：15
- 期：1
- 全文大小：4,582 KB
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Ming-Zhu Ding (1) (2)
Qian Ma (1) (2)
Xiu-Tao Dong (1) (2)
Ying-Jin Yuan (1) (2)
1. Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, People’s Republic of China
2. SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin, 300072, People’s Republic of China - 刊物类别：Chemistry and Materials Science
- 刊物主题：Biotechnology
Applied Microbiology
Environmental Engineering/Biotechnology - 出版者：BioMed Central
- ISSN：1475-2859
文摘
Background In the industry, the conventional two-step fermentation method was used to produce 2-keto-l-gulonic acid (2-KGA), the precursor of vitamin C, by three strains, namely, Gluconobacter oxydans, Bacillus spp. and Ketogulonicigenium vulgare. Despite its high production efficiency, the long incubation period and an additional second sterilization process inhibit the further development. Therefore, we aimed to reorganize a synthetic consortium of G. oxydans and K. vulgare for one-step fermentation of 2-KGA and enhance the symbiotic interaction between microorganisms to perform better.
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