Coenzyme Q10 Suppresses TNF-α-Induced Inflammatory Reaction In Vitro and Attenuates Severity of Dermatitis in Mice

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• 作者：Weiwei Li ; Xiaojuan Wu ; Xiangling Xu ; Wenhan Wang ; Sijia Song ; Ke Liang…
• 关键词：coenzyme Q10 ; TNF ; α ; inflammation ; dermatitis ; NF ; κB signaling
• 刊名：Inflammation
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：39
• 期：1
• 页码：281-289
• 全文大小：5,888 KB
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• 作者单位：Weiwei Li (1)
  Xiaojuan Wu (2)
  Xiangling Xu (3)
  Wenhan Wang (1)
  Sijia Song (1)
  Ke Liang (1)
  Min Yang (1)
  Linlin Guo (2)
  Yunpeng Zhao (4)
  Ruifeng Li (2)
  
  1. Department of Pathology, Qilu Hospital, Shandong University, Jinan, Shandong, 250012, People’s Republic of China
  2. Department of Pathology and Physiopathology, Shandong University Medical School, 44 Wenhuaxi Road, Jinan, Shandong, 250012, People’s Republic of China
  3. Department of Gynaecology and Obstetrics, Jinan Central Hospital, Shandong University, Jinan, Shandong, 250012, People’s Republic of China
  4. Department of Orthopaedics, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Jinan, Shandong, 250012, People’s Republic of China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Rheumatology
  Internal Medicine
  Pharmacology and Toxicology
  Pathology
  
• 出版者：Springer Netherlands
• ISSN：1573-2576

文摘

Anti-oxidant coenzyme Q10 (Co-Q10) is commonly used in clinic. Recently, Co-Q10 was reported to antagonize TNF-α-induced inflammation and play a protective role in various inflammatory conditions. However, its role in dermatitis is unknown. Herein, RAW264.7 macrophage cell line was cultured with stimulation of TNF-α, and administration of Co-Q10 alleviated TNF-α-mediated inflammatory reaction in vitro. Furthermore, oxazolone-induced dermatitis mice model was established, and treatment of Co-Q10 markedly attenuated dermatitis phenotype in this mice model. Moreover, the protective role of Co-Q10 in vitro and in dermatitis was probably due to its repression on NF-κB signaling. Collectively, Co-Q10 may represent a potential molecular target for prevention and treatment of inflammatory skin diseases. KEY WORDS coenzyme Q10 TNF-α inflammation dermatitis NF-κB signaling