Effects of Administration of Amlodipine and Lacidipine on Inflammation-Induced Bone Loss in the Ovariectomized Rat

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• 作者：Emre Karakus ; Zekai Halici ; Abdulmecit Albayrak ; Yasin Bayir ; Elif Demirci…
• 关键词：amlodipine ; lacidipine ; bone mineral density ; ovariectomized rat ; inflammation
• 刊名：Inflammation
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：39
• 期：1
• 页码：336-346
• 全文大小：895 KB
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• 作者单位：Emre Karakus (1)
  Zekai Halici (2)
  Abdulmecit Albayrak (2)
  Yasin Bayir (3)
  Elif Demirci (4)
  Ali Aydin (5)
  Berna Ozturk-Karagoz (6)
  Elif Cadirci (2)
  Arif Kursat Ayan (7)
  Ali Sahin (7)
  Deniz Unal (8)
  
  1. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ataturk University, 25240, Erzurum, Turkey
  2. Department of Pharmacology, Faculty of Medicine, Ataturk University, Erzurum, Turkey
  3. Department of Biochemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
  4. Department of Pathology, Faculty of Medicine, Ataturk University, Erzurum, Turkey
  5. Department of Orthopedics and Traumatology, Ataturk University Faculty of Medicine, Erzurum, Turkey
  6. Department of Pharmacology, Faculty of Pharmacy, Ibrahim Cecen University, Agrı, Turkey
  7. Department of Nuclear Medicine, Faculty of Medicine, Ataturk University, Erzurum, Turkey
  8. Department of Histology and Embryology, Faculty of Medicine, Ataturk University, Erzurum, Turkey
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Rheumatology
  Internal Medicine
  Pharmacology and Toxicology
  Pathology
  
• 出版者：Springer Netherlands
• ISSN：1573-2576

文摘

This study was performed to evaluate the possible protective effect of two calcium channel blocker’s “lacidipine (LAC) and amlodipine (AML)” on bone metabolism in an experimental ovariectomized and inflammation-induced osteoporosis rat model (OVXinf). For the purpose of this study, the rats were divided into eight groups, each containing eight rats: sham-operated control (group 1, SH), sham + inflammation (group 2, SHinf), ovariectomy (group 3, OVX), ovariectomy + inflammation (group 4, OVXinf), ovariectomy + LAC 4 mg/kg (group 5, OVX + LAC), ovariectomy + inflammation + LAC 4 mg/kg (group 6, OVXinf + LAC), ovariectomy + AML 5 mg/kg (group 7, OVX + AML), ovariectomy + inflammation + AML 5 mg/kg (group 8, OVXinf + AML). The levels of osteocalcin and osteopontin decreased in OVXinf + LAC and OVXinf + AML groups. The serum levels of TNF-α, IL-1β, and IL-6 were increased significantly in the OVXinf rats compared with the SH group. Gene expression levels of the osteogenic factor runt-related transcription factor 2 (Runx2) and type I collagen 1A1 (Col1A1) significantly decreased in the OVXinf group, when compared with the control group. AML or LAC administrations increased the levels of Runx2 and Col1A1. These results suggest that amlodipine and lacidipine may be a novel therapeutic target for radical osteoporosis treatment in hypertensive patients. KEY WORDS amlodipine lacidipine bone mineral density ovariectomized rat inflammation