参考文献:1.Chen W, Gao N, Shen Y, Cen JN. Hypermethylation downregulates Runx3 gene expression and its restoration suppresses gastric epithelial cell growth by inducing p27 and caspase3 in human gastric cancer. J Gastroenterol Hepatol. 2010;25:823–31.PubMed CrossRef 2.Tada M, Kanai F, Tanaka Y, Sanada M, Nannya Y, Tateishi K, et al. Prognostic significance of genetic alterations detected by high-density single nucleotide polymorphism array in gastric cancer. Cancer Sci. 2010;101:1261–9.PubMed CrossRef 3.Yoshida S, Matsumoto K, Arao T, Taniguchi H, Goto I, Hanafusa T, et al. Gene amplification of ribosomal protein S6 kinase-1 and -2 in gastric cancer. Anticancer Res. 2013;33:469–75.PubMed 4.Marenne G, Real FX, Rothman N, Rodriguez-Santiago B, Perez-Jurado L, Kogevinas M, et al. Genome-wide CNV analysis replicates the association between GSTM1 deletion and bladder cancer: a support for using continuous measurement from SNP-array data. BMC Genomics. 2012;13:326.PubMed PubMedCentral CrossRef 5.Uchida M, Tsukamoto Y, Uchida T, Ishikawa Y, Nagai T, Hijiya N, et al. Genomic profiling of gastric carcinoma in situ and adenomas by array-based comparative genomic hybridization. J Pathol. 2010;221:96–105.PubMed CrossRef 6.Peng DF, Sugihara H, Mukaisho K, Tsubosa Y, Hattori T. Alterations of chromosomal copy number during progression of diffuse-type gastric carcinomas: metaphase- and array-based comparative genomic hybridization analyses of multiple samples from individual tumours. J Pathol. 2003;201:439–50.PubMed CrossRef 7.Morohara K, Nakao K, Tajima Y, Nishino N, Yamazaki K, Kaetsu T, et al. Analysis by comparative genomic hybridization of gastric cancer with peritoneal dissemination and/or positive peritoneal cytology. Cancer Genet Cytogenet. 2005;161:57–62.PubMed CrossRef 8.Leung SY, Ho C, Tu IP, Li R, So S, Chu KM, et al. Comprehensive analysis of 19q12 amplicon in human gastric cancers. Mod Pathol. 2006;19:854–63.PubMed 9.Kang JU, Kang JJ, Kwon KC, Park JW, Jeong TE, Noh SM, et al. Genetic alterations in primary gastric carcinomas correlated with clinicopathological variables by array comparative genomic hybridization. J Korean Med Sci. 2006;21:656–65.PubMed PubMedCentral CrossRef 10.Tsukamoto Y, Uchida T, Karnan S, Noguchi T, Nguyen LT, Tanigawa M, et al. Genome-wide analysis of DNA copy number alterations and gene expression in gastric cancer. J Pathol. 2008;216:471–82.PubMed CrossRef 11.Takada H, Imoto I, Tsuda H, Sonoda I, Ichikura T, Mochizuki H, et al. Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization. Cancer Sci. 2005;96:100–10.PubMed CrossRef 12.Weiss MM, Kuipers EJ, Postma C, Snijders AM, Pinkel D, Meuwissen SG, et al. Genomic alterations in primary gastric adenocarcinomas correlate with clinicopathological characteristics and survival. Cell Oncol. 2004;26:307–17.PubMed 13.Jun KH, Kim SY, Yoon JH, Song JH, Park WS. Amplification of the UQCRFS1 gene in gastric cancers. J Gastric Cancer. 2012;12:73–80.PubMed PubMedCentral CrossRef 14.Park CH, Rha SY, Jeung HC, Kang SH, Ki DH, Lee WS, et al. Identification of novel gastric cancer-associated CNVs by integrated analysis of microarray. J Surg Oncol. 2010;102:454–61.PubMed CrossRef 15.Varis A, van Rees B, Weterman M, Ristimaki A, Offerhaus J, Knuutila S. DNA copy number changes in young gastric cancer patients with special reference to chromosome 19. Br J Cancer. 2003;88:1914–9.PubMed PubMedCentral CrossRef 16.Stocks SC, Pratt N, Sales M, Johnston DA, Thompson AM, Carey FA, et al. Chromosomal imbalances in gastric and esophageal adenocarcinoma: specific comparative genomic hybridization-detected abnormalities segregate with junctional adenocarcinomas. Genes Chromosomes Cancer. 2001;32:50–8.PubMed CrossRef 17.Gumus-Akay G, Unal AE, Elhan AH, Bayar S, Karadayt K, Sunguroglu A, et al. DNA copy number changes in gastric adenocarcinomas: high resolution-comparative genomic hybridization study in Turkey. Arch Med Res. 2009;40:551–60.PubMed CrossRef 18.Canales RD, Luo Y, Willey JC, Austermiller B, Barbacioru CC, Boysen C, et al. Evaluation of DNA microarray results with quantitative gene expression platforms. Nat Biotechnol. 2006;24:1115–22.PubMed CrossRef 19.Huang LYD, Wu C, Zhai K, Jiang G, Cao G, Wang C, Liu Y, Sun M, Li Z, Tan W, Lin D. Copy number variation at 6q13 functions as a long-range regulator and is associated with pancreatic cancer risk. Carcinogenesis. 2011;33:94–100.PubMed CrossRef 20.van Heumen BW, Roelofs HM, te Morsche RH, Nagengast FM, Peters WH. Duodenal mucosal risk markers in patients with familial adenomatous polyposis: effects of celecoxib/ursodeoxycholic acid co-treatment and comparison with patient controls. Orphanet J Rare Dis. 2013;8:181.PubMed PubMedCentral CrossRef 21.Ajani JA, Bentrem DJ, Besh S, D’Amico TA, Das P, Denlinger C, et al. Gastric cancer, version 2.2013: featured updates to the NCCN guidelines. J Natl Compr Cancer Netw. 2013;11:531–46. 22.Yu S, Bittel DC, Kibiryeva N, Zwick DL, Cooley LD. Validation of the Agilent 244 K oligonucleotide array-based comparative genomic hybridization platform for clinical cytogenetic diagnosis. Am J Clin Pathol. 2009;132:349–60.PubMed CrossRef 23.El Gammal AT, Bruchmann M, Zustin J, Isbarn H, Hellwinkel OJ, Kollermann J, et al. Chromosome 8p deletions and 8q gains are associated with tumor progression and poor prognosis in prostate cancer. Clin Cancer Res. 2010;16:56–64.PubMed CrossRef 24.Ribeiro FR, Jeronimo C, Henrique R, Fonseca D, Oliveira J, Lothe RA, et al. 8q gain is an independent predictor of poor survival in diagnostic needle biopsies from prostate cancer suspects. Clin Cancer Res. 2006;12:3961–70.PubMed CrossRef 25.Klatte T, Kroeger N, Rampersaud EN, Birkhauser FD, Logan JE, Sonn G, et al. Gain of chromosome 8q is associated with metastases and poor survival of patients with clear cell renal cell carcinoma. Cancer. 2012;118:5777–82.PubMed CrossRef 26.Roessler S, Long EL, Budhu A, Chen Y, Zhao X, Ji J, et al. Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival. Gastroenterology. 2012;142:957–66.e12.PubMed PubMedCentral CrossRef 27.Helms MW, Kemming D, Pospisil H, Vogt U, Buerger H, Korsching E, et al. Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease. Br J Cancer. 2008;99:774–80.PubMed PubMedCentral CrossRef 28.Kratz JR, He J, Van Den Eeden SK, Zhu ZH, Gao W, Pham PT, et al. A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies. Lancet. 2012;379:823–32.PubMed PubMedCentral CrossRef 29.Leal MF, Calcagno DQ, de Fátima Ferreira Borges da Costa J, Silva TC, Khayat AS, Chen ES, et al. MYC, TP53, and chromosome 17 copy-number alterations in multiple gastric cancer cell lines and in their parental primary tumors. J Biomed Biotechnol. 2011;2011:631268.PubMed PubMedCentral CrossRef 30.Calcagno DQ, Freitas VM, Leal MF, de Souza CR, Demachki S, Montenegro R, et al. MYC, FBXW7 and TP53 copy number variation and expression in gastric cancer. BMC Gastroenterol. 2013;13:141.PubMed PubMedCentral CrossRef 31.de Souza CR, Leal MF, Calcagno DQ, Costa Sozinho EK, Borges Bdo N, Montenegro RC, et al. MYC deregulation in gastric cancer and its clinicopathological implications. PLoS One. 2013;8:e64420.PubMed PubMedCentral CrossRef 32.Zhang L, Hou Y, Ashktorab H, Gao L, Xu Y, Wu K, et al. The impact of C-MYC gene expression on gastric cancer cell. Mol Cell Biochem. 2010;344:125–35.PubMed PubMedCentral CrossRef 33.Holen I, Cross SS, Neville-Webbe HL, Cross NA, Balasubramanian SP, Croucher PI, et al. Osteoprotegerin (OPG) expression by breast cancer cells in vitro and breast tumours in vivo—a role in tumour cell survival? Breast Cancer Res Treat. 2005;92:207–15.PubMed CrossRef 34.Holen I, Shipman CM. Role of osteoprotegerin (OPG) in cancer. Clin Sci (Lond). 2006;110:279–91.CrossRef 35.Chen G, Sircar K, Aprikian A, Potti A, Goltzman D, Rabbani SA. Expression of RANKL/RANK/OPG in primary and metastatic human prostate cancer as markers of disease stage and functional regulation. Cancer. 2006;107:289–98.PubMed CrossRef 36.Ito R, Nakayama H, Yoshida K, Kuraoka K, Motoshita J, Oda N, et al. Expression of osteoprotegerin correlates with aggressiveness and poor prognosis of gastric carcinoma. Virchows Arch. 2003;443:146–51.PubMed CrossRef 37.Neville-Webbe HL, Cross NA, Eaton CL, Nyambo R, Evans CA, Coleman RE, et al. Osteoprotegerin (OPG) produced by bone marrow stromal cells protects breast cancer cells from TRAIL-induced apoptosis. Breast Cancer Res Treat. 2004;86:269–79.PubMed CrossRef 38.Lane D, Matte I, Rancourt C, Piche A. Osteoprotegerin (OPG) protects ovarian cancer cells from TRAIL-induced apoptosis but does not contribute to malignant ascites-mediated attenuation of TRAIL-induced apoptosis. J Ovarian Res. 2012;5:34.PubMed PubMedCentral CrossRef 39.De Toni EN, Thieme SE, Herbst A, Behrens A, Stieber P, Jung A, et al. OPG is regulated by β-catenin and mediates resistance to TRAIL-induced apoptosis in colon cancer. Clin Cancer Res. 2008;14:4713–8.PubMed CrossRef
作者单位:Xiaohong Wang (1) Yiqiang Liu (2) Duanfang Shao (3) Ziliang Qian (4) Zhengwei Dong (4) Yun Sun (4) Xiaofang Xing (3) Xiaojing Cheng (3) Hong Du (3) Ying Hu (1) Yingai Li (1) Lin Li (3) Bin Dong (2) Ziyu Li (3) Aiwen Wu (3) Xiaojiang Wu (3) Zhaode Bu (3) Xianglong Zong (3) Guanshan Zhu (4) Qunsheng Ji (4) Xian-zi Wen (3) Lian-hai Zhang (3) Jia-fu Ji (3)
1. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Tissue Bank, Peking University Cancer Hospital and Institute, Beijing, 100142, China 2. Department of Pathology, Peking University Cancer Hospital and Institute, Beijing, 100142, China 3. Department of Surgery, Peking University Cancer Hospital and Institute, Beijing, 100142, China 4. Asia and Emerging Markets Innovative Medicine, AstraZeneca R&D, Shanghai, 201203, China
刊物类别:Medicine
刊物主题:Medicine & Public Health Oncology Gastroenterology Surgical Oncology Pathology Radiotherapy
出版者:Springer Japan
ISSN:1436-3305
文摘
Background Gastric cancer (GC) is an aggressive malignancy whose mechanisms of development and progression are poorly understood. The identification of prognosis-related genomic loci and genes may suffer from the relatively small case numbers and a lack of systematic validation in previous studies.