TNP-ATP is Beneficial for Treatment of Neonatal Hypoxia-Induced Hypomyelination and Cognitive Decline

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• 作者：Jie Xiao ; Yilong Huang ; Xia Li ; Longjun Li ; Ting Yang…
• 关键词：Neonatal hypoxia ; Inflammation ; Ionotropic ATP receptors ; Glutamate ; Memory deficit
• 刊名：Neuroscience Bulletin
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：32
• 期：1
• 页码：99-107
• 全文大小：1,155 KB
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• 作者单位：Jie Xiao (1)
  Yilong Huang (1)
  Xia Li (1)
  Longjun Li (1)
  Ting Yang (1)
  Lixuan Huang (1)
  Ling Yang (1)
  Hong Jiang (1)
  Hongchun Li (1)
  Fan Li (1)
  
  1. Department of Pathology and Pathophysiology, School of Basic Medical Science, Kunming Medical University, Kunming, 650500, China
  
• 刊物主题：Neurosciences; Human Physiology; Anesthesiology; Anatomy; Neurology; Pain Medicine;
• 出版者：Springer Berlin Heidelberg
• ISSN：1995-8218

文摘

Our previous study together with other investigations have reported that neonatal hypoxia or ischemia induces long-term cognitive impairment, at least in part through brain inflammation and hypomyelination. However, the detailed mechanisms are not fully understood. Here, we used a rodent model of neonatal hypoxia by subjecting postnatal day 0 (P0) rat pups to systemic hypoxia (3.5 h). We found that neonatal hypoxia increased the glutamate content and initiated inflammatory responses at 4 h and 1 day after hypoxia, caused hypomyelination in the corpus callosum, and impaired hippocampus-dependent learning and memory when assessed 30–60 days after hypoxia. Interestingly, much of the hypoxia-induced brain damage was ameliorated by treatment with the ATP analogue 2′,3′-0-(2,4,6-trinitrophenyl)-adenosine 5′-triphosphate (TNP-ATP; blocks all ionotropic P2X1-7 receptors), whereas treatment with pyridoxalphosphate-6-azophenyl-2′,4′-disulphonic acid (PPADS; inhibits P2X1-3 and P2X5-7 receptors) was less neuroprotective. Our data indicated that activation of ionotropic ATP receptors might be partially, if not fully, involved in glutamate deregulation, neuroinflammation, hypomyelination, and cognitive dysfunction after neonatal hypoxia. Keywords Neonatal hypoxia Inflammation Ionotropic ATP receptors Glutamate Memory deficit