Single nucleotide polymorphisms (SNPs) of hOGG1 and XRCC1 DNA repair genes and the risk of ovarian cancer in Polish women

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• 作者：Magdalena M. Michalska ; Dariusz Samulak ; Hanna Romanowicz ; Jan Bieńkiewicz…
• 关键词：Ovarian cancer ; hOGG1 ; XRCC1 ; Polymorphism
• 刊名：Tumor Biology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：36
• 期：12
• 页码：9457-9463
• 全文大小：280 KB
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• 作者单位：Magdalena M. Michalska (1)
  Dariusz Samulak (1) (2)
  Hanna Romanowicz (3)
  Jan Bieńkiewicz (4)
  Maciej Sobkowski (5)
  Krzysztof Ciesielski (6)
  Beata Smolarz (3)
  
  1. Department of Obstetrics and Gynaecology, Regional Hospital in Kalisz, Kalisz, Poland
  2. Cathedral of Mother’s and Child’s Health, Poznan University of Medical Sciences, Poznań, Poland
  3. Laboratory of Cancer Genetics, Department of Pathology, Institute of Polish Mother’s Memorial Hospital, Rzgowska 281/289, 93-338, Lodz, Poland
  4. Department of Surgical, Endoscopic and Oncologic Gynaecology, Institute of Polish Mother’s Memorial Hospital, Lodz, Poland
  5. Department of Obstetrics and Gynaecology, University Hospital, Polna 33, Poznań, Poland
  6. Department of Surgery, Hospital in Glowno, Glowno, Poland
  
• 刊物主题：Cancer Research;
• 出版者：Springer Netherlands
• ISSN：1423-0380

文摘

The aim of this study was to determine single nucleotide polymorphisms in hOGG1 (Ser326Cys (rs13181)) and XRCC1 (Arg194Trp (rs1799782)) genes, respectively, and to identify the correlation between them and the overall risk, grading and staging of ovarian cancer in Polish women. Our study comprised 720 patients diagnosed with ovarian cancer and 720 healthy controls. The genotype analysis of hOGG1 and XRCC1 polymorphisms was performed using polymerase chain reaction (PCR)-based restriction fragment length polymorphism (PCR-RFLP). Odds ratios (OR) and 95 % confidence intervals (CI) for each genotype and allele were calculated. Results revealed an association between hOGG1 Ser326Cys polymorphism and the incidence of ovarian cancer. Variant Cys allele of hOGG1 increased the overall cancer risk (OR 2.89; 95 % CI 2.47–3.38; p < .0001). Moreover, ovarian cancer grading remained in a relationship with both analysed polymorphisms; G1 tumours presented increased frequencies of hOGG1 Cys/Cys homozygotes (OR 18.33; 95 % CI 9.38–35.81; p < .0001) and XRCC1 Trp/Trp homozygotes (OR 20.50; 95 % CI 10.17–41.32; p < .0001). Furthermore, G1 ovarian cancers displayed an overrepresentation of Cys and Trp allele. In conclusion, hOGG1 Ser326Cys and XRCC1 Arg194Trp polymorphisms may be regarded as risk factors of ovarian cancer. Keywords Ovarian cancer hOGG1 XRCC1 Polymorphism