Anti-tumor effects of pigment epithelium-derived factor (PEDF): implication for cancer therapy. A mini-review

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• 作者：Louiza Belkacemi ; Shaun Xiaoliu Zhang
• 关键词：Anticancer agents ; Cancer ; Pigment epidermal derived factor ; Phosphaplatins
• 刊名：Journal of Experimental & Clinical Cancer Research
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：35
• 期：1
• 全文大小：1,114 KB
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• 作者单位：Louiza Belkacemi (1)
  Shaun Xiaoliu Zhang (1) (2)
  
  1. Department of Biology and Biochemistry, University of Houston, Houston, TX, 77204, USA
  2. Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX, 77204, USA
  
• 刊物主题：Oncology; Cancer Research;
• 出版者：BioMed Central
• ISSN：1756-9966

文摘

Pigment epithelium-derived factor (PEDF) is a secreted glycoprotein and a non-inhibitory member of the serine protease inhibitor (serpin) family. It is widely expressed in human fetal and adult tissues but its expression decreases with age and in malignant tissues. The main anti-cancer activities of PEDF derive from its dual effects, either indirectly on the tumor microenvironment (indirect antitumor action) or directly on the tumor itself (direct antitumor influence). The indirect antitumor activities of PEDF were uncovered from the early findings that it stimulates retinoblastoma cell differentiation and that additionally it possesses anti-angiogenic, anti-tumorigenic and anti-metastatic properties. The mechanisms of its direct antitumor effect, however, have not been fully elucidated. This review highlights recent progress in our understanding of the multifunctional activities of PEDF and, in particular, its anti-cancer signaling mechanisms. Additionally, we discuss the possibility of using novel phosphaplatin compounds that can upregulate PEDF expression as a chemotherapy for cancer treatment. Keywords Anticancer agents Cancer Pigment epidermal derived factor Phosphaplatins