Green Synthesis of Oxovanadium(IV)/chitosan Nanocomposites and Its Ameliorative Effect on Hyperglycemia, Insulin Resistance, and Oxidative Stress

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• 作者：Yanjun Liu ; Xu Jie ; Yongli Guo ; Xin Zhang…
• 关键词：Oxovanadium(IV)/chitosan nanocomposites ; Chitosan ; Hyperglycemia ; Insulin resistance ; Oxidative stress
• 刊名：Biological Trace Element Research
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：169
• 期：2
• 页码：310-319
• 全文大小：701 KB
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• 作者单位：Yanjun Liu (1)
  Xu Jie (1)
  Yongli Guo (1)
  Xin Zhang (1)
  Jingfeng Wang (1)
  Changhu Xue (1)
  
  1. College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, 266003, Qingdao, Shandong Province, China
  
• 刊物主题：Biochemistry, general; Biotechnology; Nutrition; Oncology;
• 出版者：Springer US
• ISSN：1559-0720

文摘

In this paper, the preparation, characterization, and ameliorative effect on high-fat high-sucrose diet-induced hyperglycemia, insulin resistance, oxidative stress in mice of novel oxovanadium(IV)/chitosan (OV/CS) nanocomposites were investigated. The nanobiocomposite was produced by chemical reduction by chitosan and L-ascorbic acid using microwave heating, under environment-friendly conditions, using aqueous solutions, and notably, by using both mediators as reducing and stabilizing agents. In addition, OV/CS nanocomposites were characterized by transmission electron microscopy, energy dispersive spectroscopy, particle size, and zeta potential measurements. In vivo experiments were designed to examine whether the OV/CS nanocomposites would provide additional benefits on oxidative stress, hyperglycemia, and insulin resistance in mice with type 2 diabetes. The results rendered insulin resistant by treating with OV/CS nanocomposites alleviate insulin resistance and improve oxidative stress. Such nanocomposite seem to be a valuable therapy to achieve and/or maintain glycemic control and therapeutic agents in the treatment arsenal for insulin resistance and type 2 diabetes. Keywords Oxovanadium(IV)/chitosan nanocomposites Chitosan Hyperglycemia Insulin resistance Oxidative stress