Characterization of MTNR1A gene in terms of genetic variability in a panel of subtemperate and subtropical Indian sheep breeds

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• 作者：VIJAY KUMAR SAXENA ; BIPUL KUMAR JHA ; AMAR SINGH MEENA…
• 关键词：MTNR1A gene ; seasonality ; genotype ; polymorphism.
• 刊名：Journal of Genetics
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：94
• 期：4
• 页码：715-721
• 全文大小：663 KB
• 参考文献：Acharya R. M. 1982 Sheep and goat breeds of Indian animal production and health paper 30. Food and Agricultural Organization of United Nations, Rome, Italy.
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• 作者单位：VIJAY KUMAR SAXENA (1)
  BIPUL KUMAR JHA (1)
  AMAR SINGH MEENA (2)
  S. M. K. NAQVI (1)
  
  1. Division of Physiology and Biochemistry, Central Sheep and Wool Research Institute, Malpura, 304 501, India
  2. Division of Animal Biotechnology, Central Sheep and Wool Research Institute, Malpura, 304 501, India
  
• 刊物主题：Life Sciences, general; Microbial Genetics and Genomics; Plant Genetics & Genomics; Animal Genetics and Genomics; Evolutionary Biology;
• 出版者：Springer India
• ISSN：0973-7731

文摘

Seasonality of animals is an important adaptive trait for successful survival and production during limited food availability and extreme environmental conditions. Photoperiodic changes in day length are utilized by these seasonal animals as an important environmental cue for regulating their annual rhythms of reproduction cycles. Melatonin is an important hormone which is secreted by the pineal gland in proportion to darkness and its effect is mediated by melatonin receptor subtypes, principally MTNR1A. In the present study, polymorphism in the coding sequence at two important SNPs (C606T and G612A), known to be markers for out of season breeding in sheep were studied by PCR-RFLP in a panel of four breeds of sheep from subtemperate and subtropical arid conditions, respectively. The frequencies of ‘G’ and ‘A’ alleles with reference to G612A SNP did not differ considerably among all the breeds of sheep. Frequency of ‘T’ allele of the C606T SNP was found to be dominantly higher in subtemperate sheep breeds in comparison to subtropical sheep breeds. Identified SNPs in the coding region were mostly synonymous and did not lead to any change in conformation of the MTNR1A receptor protein. Keywords MTNR1A gene seasonality genotype polymorphism.