Alterations of amino acid metabolism in osteoarthritis: its implications for nutrition and health

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• 作者：Yusheng Li ; Wenfeng Xiao ; Wei Luo ; Chao Zeng ; Zhenhan Deng ; Wenkai Ren…
• 关键词：Arginine ; Glutamate ; Glutamine ; Inflammation ; Osteoarthritis
• 刊名：Amino Acids
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：48
• 期：4
• 页码：907-914
• 全文大小：489 KB
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• 作者单位：Yusheng Li (1)
  Wenfeng Xiao (1)
  Wei Luo (1)
  Chao Zeng (1)
  Zhenhan Deng (1)
  Wenkai Ren (2)
  Guoyao Wu (3)
  Guanghua Lei (1)
  
  1. Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China
  2. Laboratory of Animal Nutrition and Health and Key Laboratory of Agro-Ecology, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, 410125, Hunan, China
  3. Department of Animal Science, Texas A&M University, 2471 TAMU, College Station, TX, 77843-2471, USA
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Analytical Chemistry
  Biochemical Engineering
  Life Sciences
  Proteomics
  Neurobiology
  
• 出版者：Springer Wien
• ISSN：1438-2199

文摘

Osteoarthritis (OA) is a common form of arthritis in humans. It has long been regarded as a non-inflammatory disease, but a degree of inflammation is now recognized as being a vital inducer of subpopulation of OA. Besides inflammation, the establishment and development of OA are associated with alterations in metabolism and profiles of amino acids (AA), including glutamate- and arginine-family AA as well as their related metabolites (e.g., creatinine, hydroxyproline, γ-aminobutyrate, dimethylarginines and homoarginine). Functional AA (e.g., glutamine, arginine, glutamate, glycine, proline, and tryptophan) have various benefits (i.e., anti-inflammation and anti-oxidation) in treatment of inflammation-associated diseases, including OA. Thus, these AA have potential as immunomodulatory nutrients for patients with inflammation-induced OA.