Comparative biological parameters for the evaluation of common renal pharmaceutical preparations: 99mTc-DTPA, 99mTc-GH, and 99mTc-DMSA

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• 作者：Hisham M. A. Al-Azzawi ; Saadi M. D. Al-Nuzal…
• 关键词：Quality control ; 99mTc ; DTPA ; 99mTc ; GH and 99mTc ; DMSA renal preparations ; Radiochemical purity ; Plasma protein binding
• 刊名：Journal of Radioanalytical and Nuclear Chemistry
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：307
• 期：1
• 页码：123-130
• 全文大小：469 KB
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• 作者单位：Hisham M. A. Al-Azzawi (1)
  Saadi M. D. Al-Nuzal (2)
  Jameel M. Badi (1)
  
  1. Directorate of Research and Nuclear Applications, Ministry of Science Technology, Al-Jadriyia, P.O. 765, Baghdad, Iraq
  2. Environmental Research Centre, The University of Technology, Baghdad, Iraq
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nuclear Chemistry
  Physical Chemistry
  Nuclear Physics, Heavy Ions and Hadrons
  Diagnostic Radiology
  Inorganic Chemistry
  
• 出版者：Akad茅miai Kiad贸, co-published with Springer Science+Business Media B.V., Formerly Kluwer Academic
• ISSN：1588-2780

文摘

This work is concerned on establishing the necessary comparative quality control biological parameters for the evaluation of locally produced renal pharmaceutical preparations viz. tin complexes of 99mTc-DTPA, 99mTc-GH, and 99mTc-DMSA using gel chromatography column scanning techniques. Radiochemical purity, labeling yields, organ distribution, blood clearance and plasma protein binding were used as a selected indicator for quality control. The higher renal accumulation and tissue distribution were apparent with 99mTc-DTPA in mice, while blood retention was considerably low. The blood clearance of 99mTc-DMSA was relatively slow, while that of 99mTc-GH was rapid. The binding of 99mTc-DTPA, 99mTc-GH and 99mTc-DMSA with plasma protein were found to be 5, 65, and 95 % at 1.0 h, respectively. The stability of these cold kits was not affected on storing at 37 °C for 30 days.