Preparation of heparin-functionalized microspheres and study on their adsorption characteristic for basic protein lysozyme

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• 作者：Jiying Men ; Ruixin Wang ; Xiaoyu Hu ; Hongyu Zhao ; Hongwei Wei…
• 关键词：heparin ; lysozyme ; adsorption ; low density lipoprotein (LDL)
• 刊名：Macromolecular Research
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：24
• 期：2
• 页码：114-122
• 全文大小：584 KB
• 参考文献：(1).J. Couzin, Science, 322, 220 (2008).CrossRef
  (2).K. M. Fox, S. K. Gandhi, M. F. Bullano, R. L. Ohsfeldt, and M. H. Davidson, Circulation, 117, E425 (2008).
  (3).A. M. Chamberlain, A. R. Folsom, P. J. Schreiner, E. Boerwinkle, and C. M. Ballantyne, Atherosclerosis, 200, 322 (2008).CrossRef
  (4).T. Shoji, S. Hatsuda, S. Tsuchikura, K. Shinohara, E. Kimoto, H. Koyama, M. Emoto, and Y. Nishizawa, Atherosclerosis, 202, 582 (2009).CrossRef
  (5).R. Bambauer, R. Schiel, and R. Latza, Ther. Apheresis Dial., 7, 382 (2003).CrossRef
  (6).T. Bosch, Ther. Apheresis Dial., 9, 459 (2005).CrossRef
  (7).D. B. Liu, B. J. He, S. Y. Han, S. Q. Wang, Q. P. Liu, A. Jun ichi, T. Osa, and Q. Chen, Mater. Sci. Eng. C, 27, 665 (2007).CrossRef
  (8).B. G. Stegmayr, Transfus. Apher. Sci., 32, 209 (2005).CrossRef
  (9).P. J. Soltys and M. R. Etzel, Biomaterials, 21, 37 (2000).CrossRef
  (10).H. T. Li, Y. M. Zhang, X. F. Chen, K. Y. Shi, Z. Yuan, B. Liu, B. Shen, and B. L. He, React. Funct. Polym., 58, 53 (2004).CrossRef
  (11).S. Q. Wang, Y. T. Yu, T. Cui, and Y. Cheng, Biomaterials, 24, 2799 (2003).CrossRef
  (12).T. Bosch, B. Schmidt, W. Kleophas, C. Gillen, V. Otto, J. Passlick-Deetjen, and H. J. Gurland, Artif. Organs, 21, 977 (1997).CrossRef
  (13).H. Borberg, Transfus. Apher. Sci., 41, 49 (2009).CrossRef
  (14).W. Wang, X. J. Huang, J. D. Cao, P. Lan, and W. Wu, Acta BiolnKmater., 10, 234 (2014).CrossRef
  (15).L. R. Zhao, D. X. Sun, and M. Y. Liu, Carbohydr. Polym., 78, 828 (2009).CrossRef
  (16).X. J. Huang, D. Guduru, Z. K. Xu, J. Vienken, and T. Groth, Acta Biomater., 6, 1099 (2010).CrossRef
  (17).K. W. Ma, L. Ma, S. X. Cai, X. Wang, B. Liu, and Z. L. Xu, J. Mater. Sci. Mater. Med., 19, 3255 (2008).CrossRef
  (18).X. M. Zheng, X. J. Huang, and Z. K. Xu, Acta Polym. Sin., 7, 791 (2011).CrossRef
  (19).S. E. Kim, C. S. Kim, Y. P. Yun, D. H. Yang, K. Park, S. E. Kim, C. M. Jeong, and J. B. Huh, Carbohydr. Polym., 114, 123 (2014).CrossRef
  (20).S. Yu, Z. T. Yu, G. Wang, M. S. Dargusch, and M. H. Zhang, Rare Metal Mater. Eng., 38, 0384 (2009).CrossRef
  (21).Y. Deng, Y. H. Sun, X. F. Chen, P. Z. Zhu, and S. C. Wei, Mater. Sci. Eng. C, 3, 2905 (2013).CrossRef
  (22).L. Buzoglu, E. Maltas, M. Ersoz, and S. Yildiz, React. Funct. Polym., 82, 25 (2014).CrossRef
  (23).Y. L. Sun and Y. W. Yan, J. Control. Release, 172, E14 (2013).
  (24).M. A. Abd El-Ghaffar, M. S. Hashem, M. K. El-Awady, and A. M. Rabie, Carbohydr. Polym., 89, 667 (2012).CrossRef
  (25).F. Li, M. Ma, Z. F. Yuan, J. Y. Huang, and R. X. Zhuo, J. Bioact. Compat. Polym., 26, 388 (2011).CrossRef
  (26).T. S. Christine and A. B. Ipsita, Materials, 2, 577 (2009).CrossRef
  (27).P. F. Li, L. R. Yang, X. Q. He, J. Wang, P. Kong, H. F. Xing, and H. Z. Liu, J. Chem. Eng., 20, 95 (2012).
  (28).Y. L.Yu, B. J. Gao, and Y. F. Li, Chinese J. Catal., 34, 1776 (2013).CrossRef
  (29).Z. Tong, Silicone Mater., 26, 258 (2012).
  (30).X. J. Huang, D. Guduru, Z. K. Xu, J. Vienken, and T. Groth, Acta Biomater., 6, 1099 (2010).CrossRef
  (31).B. J.Gao, H. Y. Fu, Y. B. Li, and R. K. Du, J. Chromatogr. B, 878, 1731 (2010).CrossRef
  (32).H. Y. Guo, Y. M. Wu, J. Yuan, and F. F. Yang, Sep. Sci. Technol., 49, 2548 (2014).CrossRef
  (33).A. R. Cestari, E. F. S. Vieira, and C. R. S. Mattos, J. Chem. Thermodyn., 38, 1092 (2006).CrossRef
  (34).F. S. C. Anjos, E. F. S. Vieira, and A. R. Cestari1, J. Colloid Interface Sci., 253, 243 (2002).CrossRef
  (35).A. R. Cestari, E. F. S. Vieira, and C. R. S. Mattos, J. Chem. Thermodyn., 38, 1092 (2006).CrossRef
  (36).Y. Y. Zhang, B. J. Gao, and Z. Q. Xu, J. Phys. Chem. B, 117, 5730 (2013).CrossRef
  
• 作者单位：Jiying Men (1)
  Ruixin Wang (1)
  Xiaoyu Hu (1)
  Hongyu Zhao (1)
  Hongwei Wei (1)
  Cong Hu (1)
  Baojiao Gao (1)
  
  1. Department of Chemical engineering, North University of China, Taiyuan, 030051, P. R. China
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Physical Chemistry
  Polymer Sciences
  Characterization and Evaluation of Materials
  Soft and Granular Matter, Complex Fluids and Microfluidics
  Nanochemistry
  Nanotec
  
• 出版者：The Polymer Society of Korea, co-published with Springer
• ISSN：2092-7673

文摘

In suspension polymerization system, poly(glycidyl methacrylate) (PGMA) microspheres are firstly prepared. Then, ring opening reaction takes place when heparin is bonded on PGMA microspheres to obtain functional PGMA-heparin microspheres. The chemical structure and physicochemical characters of PGMA-heparin microspheres are fully characterized with infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and zeta potential determination. The adsorption properties of PGMA-heparin for lysozyme are mainly investigated. The effects of the main factors on the adsorption properties are explored, furthermore the adsorption mechanism is analyzed in depth, and the adsorption thermodynamics is also researched. The experimental results show that the strong electrostatic interaction is formed between high density of negative charge coming from the carboxyl groups or sulfonic acid groups of heparin and the positive charge of basic protein lysozyme. The adsorption of PGMA-heparin for lysozyme is dependent on the pH value of the medium, and the saturated adsorption amount of PGMA-heparin for lysozyme possesses a maximum at pH 8, which reaches up to 654 mg/g. The adsorption of PGMA-heparin for lysozyme is an exothermic process which is driven by entropy, and the adsorption amount decreases with increasing the temperature. Keywords heparin lysozyme adsorption low density lipoprotein (LDL) Page %P Close Plain text Look Inside Reference tools Export citation EndNote (.ENW) JabRef (.BIB) Mendeley (.BIB) Papers (.RIS) Zotero (.RIS) BibTeX (.BIB) Add to Papers Other actions Register for Journal Updates About This Journal Reprints and Permissions Share Share this content on Facebook Share this content on Twitter Share this content on LinkedIn Related Content Supplementary Material (0) References (36) References(1).J. Couzin, Science, 322, 220 (2008).CrossRef(2).K. M. Fox, S. K. Gandhi, M. F. Bullano, R. L. Ohsfeldt, and M. H. Davidson, Circulation, 117, E425 (2008).(3).A. M. Chamberlain, A. R. Folsom, P. J. Schreiner, E. Boerwinkle, and C. M. Ballantyne, Atherosclerosis, 200, 322 (2008).CrossRef(4).T. Shoji, S. Hatsuda, S. Tsuchikura, K. Shinohara, E. Kimoto, H. Koyama, M. Emoto, and Y. Nishizawa, Atherosclerosis, 202, 582 (2009).CrossRef(5).R. Bambauer, R. Schiel, and R. Latza, Ther. Apheresis Dial., 7, 382 (2003).CrossRef(6).T. Bosch, Ther. Apheresis Dial., 9, 459 (2005).CrossRef(7).D. B. Liu, B. J. He, S. Y. Han, S. Q. Wang, Q. P. Liu, A. Jun ichi, T. Osa, and Q. Chen, Mater. Sci. Eng. C, 27, 665 (2007).CrossRef(8).B. G. Stegmayr, Transfus. Apher. Sci., 32, 209 (2005).CrossRef(9).P. J. Soltys and M. R. Etzel, Biomaterials, 21, 37 (2000).CrossRef(10).H. T. Li, Y. M. Zhang, X. F. Chen, K. Y. Shi, Z. Yuan, B. Liu, B. Shen, and B. L. He, React. Funct. Polym., 58, 53 (2004).CrossRef(11).S. Q. Wang, Y. T. Yu, T. Cui, and Y. Cheng, Biomaterials, 24, 2799 (2003).CrossRef(12).T. Bosch, B. Schmidt, W. Kleophas, C. Gillen, V. Otto, J. Passlick-Deetjen, and H. J. Gurland, Artif. Organs, 21, 977 (1997).CrossRef(13).H. Borberg, Transfus. Apher. Sci., 41, 49 (2009).CrossRef(14).W. Wang, X. J. Huang, J. D. Cao, P. Lan, and W. Wu, Acta BiolnKmater., 10, 234 (2014).CrossRef(15).L. R. Zhao, D. X. Sun, and M. Y. Liu, Carbohydr. Polym., 78, 828 (2009).CrossRef(16).X. J. Huang, D. Guduru, Z. K. Xu, J. Vienken, and T. Groth, Acta Biomater., 6, 1099 (2010).CrossRef(17).K. W. Ma, L. Ma, S. X. Cai, X. Wang, B. Liu, and Z. L. Xu, J. Mater. Sci. Mater. Med., 19, 3255 (2008).CrossRef(18).X. M. Zheng, X. J. Huang, and Z. K. Xu, Acta Polym. Sin., 7, 791 (2011).CrossRef(19).S. E. Kim, C. S. Kim, Y. P. Yun, D. H. Yang, K. Park, S. E. Kim, C. M. Jeong, and J. B. Huh, Carbohydr. Polym., 114, 123 (2014).CrossRef(20).S. Yu, Z. T. Yu, G. Wang, M. S. Dargusch, and M. H. Zhang, Rare Metal Mater. Eng., 38, 0384 (2009).CrossRef(21).Y. Deng, Y. H. Sun, X. F. Chen, P. Z. Zhu, and S. C. Wei, Mater. Sci. Eng. C, 3, 2905 (2013).CrossRef(22).L. Buzoglu, E. Maltas, M. Ersoz, and S. Yildiz, React. Funct. Polym., 82, 25 (2014).CrossRef(23).Y. L. Sun and Y. W. Yan, J. Control. Release, 172, E14 (2013).(24).M. A. Abd El-Ghaffar, M. S. Hashem, M. K. El-Awady, and A. M. Rabie, Carbohydr. Polym., 89, 667 (2012).CrossRef(25).F. Li, M. Ma, Z. F. Yuan, J. Y. Huang, and R. X. Zhuo, J. Bioact. Compat. Polym., 26, 388 (2011).CrossRef(26).T. S. Christine and A. B. Ipsita, Materials, 2, 577 (2009).CrossRef(27).P. F. Li, L. R. Yang, X. Q. He, J. Wang, P. Kong, H. F. Xing, and H. Z. Liu, J. Chem. Eng., 20, 95 (2012).(28).Y. L.Yu, B. J. Gao, and Y. F. Li, Chinese J. Catal., 34, 1776 (2013).CrossRef(29).Z. Tong, Silicone Mater., 26, 258 (2012).(30).X. J. Huang, D. Guduru, Z. K. Xu, J. Vienken, and T. Groth, Acta Biomater., 6, 1099 (2010).CrossRef(31).B. J.Gao, H. Y. Fu, Y. B. Li, and R. K. Du, J. Chromatogr. B, 878, 1731 (2010).CrossRef(32).H. Y. Guo, Y. M. Wu, J. Yuan, and F. F. Yang, Sep. Sci. Technol., 49, 2548 (2014).CrossRef(33).A. R. Cestari, E. F. S. Vieira, and C. R. S. Mattos, J. Chem. Thermodyn., 38, 1092 (2006).CrossRef(34).F. S. C. Anjos, E. F. S. Vieira, and A. R. Cestari1, J. Colloid Interface Sci., 253, 243 (2002).CrossRef(35).A. R. Cestari, E. F. S. Vieira, and C. R. S. Mattos, J. Chem. Thermodyn., 38, 1092 (2006).CrossRef(36).Y. Y. Zhang, B. J. Gao, and Z. Q. Xu, J. Phys. Chem. B, 117, 5730 (2013).CrossRef About this Article Title Preparation of heparin-functionalized microspheres and study on their adsorption characteristic for basic protein lysozyme Journal Macromolecular Research Volume 24, Issue 2 , pp 114-122 Cover Date2016-02 DOI 10.1007/s13233-016-2016-6 Print ISSN 1598-5032 Online ISSN 2092-7673 Publisher The Polymer Society of Korea Additional Links Register for Journal Updates Editorial Board About This Journal Manuscript Submission Topics Polymer Sciences Soft and Granular Matter, Complex Fluids and Microfluidics Physical Chemistry Characterization and Evaluation of Materials Nanochemistry Nanotechnology Keywords heparin lysozyme adsorption low density lipoprotein (LDL) Industry Sectors Pharma Materials & Steel Automotive Chemical Manufacturing Biotechnology Electronics IT & Software Telecommunications Consumer Packaged Goods Aerospace Oil, Gas & Geosciences Engineering Authors Jiying Men (1) Ruixin Wang (1) Xiaoyu Hu (1) Hongyu Zhao (1) Hongwei Wei (1) Cong Hu (1) Baojiao Gao (1) Author Affiliations 1. Department of Chemical engineering, North University of China, Taiyuan, 030051, P. R. China Continue reading... To view the rest of this content please follow the download PDF link above.