Concise synthesis of two natural steroidal glycosides isolated from Allium schoenoprasum

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• 作者：Qingchao Liu ; Tiantian Guo ; Dong Li ; Wenhong Li
• 关键词：Steroidal glycosides ; Glycosylation ; Glycosyl donors ; Cytotoxic activity
• 刊名：Research on Chemical Intermediates
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：42
• 期：3
• 页码：1611-1626
• 全文大小：555 KB
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• 作者单位：Qingchao Liu (1) (2)
  Tiantian Guo (1)
  Dong Li (1)
  Wenhong Li (1)
  
  1. Department of Pharmaceutical Engineering, Northwest University, 229 Taibaibei Road, Xi’an, 710069, Shaanxi, People’s Republic of China
  2. Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Catalysis
  Physical Chemistry
  Inorganic Chemistry
  
• 出版者：Springer Netherlands
• ISSN：1568-5675

文摘

Two natural steroidal glycosides, diosgenin 3-O-α-l-rhamnopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→4)]-β-d-glucopyranoside (1) and laxogenin 3-O-α-l-rhamnopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→4)]-β-d-glucopyranoside (2) with important cytotoxic activity against the HCT 116 and HT-29 human colon cancer cell lines have been efficiently synthesized via straightforward sequential glycosylation reaction with the combined use of N-phenyltrifluoroacetimidates and trichloroacetimidates donors at room temperature. All structures of the synthesized new compounds were identified by 1H NMR, 13C NMR and HRMS spectra.