Simultaneous determination of urinary parabens, bisphenol A, triclosan, and 8-hydroxy-2᾿deoxyguanosine by liquid chromatography coupled with electrospray ionization tandem mass spectrometry

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• 作者：Lu Ren ; Jianzhang Fang ; Guihua Liu…
• 关键词：8 ; Hydroxy ; 2′-deoxyguanosine ; Bisphenol A ; Parabens ; Triclosan ; Urine
• 刊名：Analytical and Bioanalytical Chemistry
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：408
• 期：10
• 页码：2621-2629
• 全文大小：423 KB
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• 作者单位：Lu Ren (1)
  Jianzhang Fang (1)
  Guihua Liu (2)
  Jianqing Zhang (2)
  Zhou Zhu (2)
  Honghe Liu (2)
  Kai Lin (2)
  Huimin Zhang (2)
  Shaoyou Lu (2)
  
  1. School of Chemistry and Environment, South China Normal University, Guangzhou, Guangdong, 510006, China
  2. Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, 518055, China
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Analytical Chemistry
  Food Science
  Inorganic Chemistry
  Physical Chemistry
  Monitoring, Environmental Analysis and Environmental Ecotoxicology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1618-2650

文摘

A simple and fast method was developed for the simultaneous determination of five parabens, bisphenol A (BPA), triclosan (TCS), and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in human urine using liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). The solid-phase extraction (SPE) procedure, chromatographic conditions, and MS/MS parameters were optimized to achieve maximum sensitivity and accuracy for the analytes. The validation results showed that the correlation coefficients (R 2) and recoveries ranged from 0.999 to 1 and 83.9 to 109.9 %, respectively, and the intra-day and inter-day precisions (relative standard deviation, RSD) were within the range of 1.3–8.5 % and 1.3–9.0 %, respectively. The limits of detection for the analytes ranged from 0.001 to 0.05 μg/L. The method was successfully employed to determine parabens, BPA, TCS, and 8-OHdG in urine samples from school students in Guangzhou, China. The results showed that methyl, ethyl, n-propyl parabens, BPA, TCS, and 8-OHdG were frequently detected in urine samples. n-Butyl and benzyl parabens were only detected in a part of the samples due to their low concentrations in urine.