The prognostic value of EGFR overexpression and amplification in Esophageal squamous cell Carcinoma

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• 作者：Dongxian Jiang ; Xiaojing Li ; Haixing Wang ; Yuan Shi ; Chen Xu ; Shaohua Lu…
• 关键词：Esophageal squamous cell carcinoma ; Epidermal growth factor receptor ; Immunohistochemistry scoring system ; Fluorescence in situ hybridization
• 刊名：BMC Cancer
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：15
• 期：1
• 全文大小：1,478 KB
• 刊物主题：Cancer Research; Oncology; Stem Cells; Animal Models; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-2407

文摘

Background In view of the prominent role in cancer cell biology and alteration in substantial numbers of ESCC, defining EGFR molecular characteristics relevant to patient prognosis is of great importance. Therefore, we analyzed the protein expression and gene copy variation of the epithelial growth factor receptor (EGFR) in Chinese esophageal squamous cell carcinoma (ESCC) and explored the possible associations with various features of the tumors and survival of the patients.