Impairment of dendritic cell function and induction of CD4+CD25+Foxp3+ T cells by excretory-secretory products: a potential mechanism of immune evasion adopted b

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• 作者：Ying Wang ; Hejun Zhou ; Yujuan Shen ; Yanjuan Wang ; Weiping Wu ; Haipeng Liu…
• 关键词：Echinococcus granulosus ; Mechanism ; Excretory ; secretory products ; Dendritic cell ; Dendritic cell maturation ; Cytokine
• 刊名：BMC Immunology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：16
• 期：1
• 全文大小：2,518 KB
• 刊物主题：Immunology; Allergology; Vaccine; Cytokines and Growth Factors;
• 出版者：BioMed Central
• ISSN：1471-2172

文摘

Background Cystic echinococcosis, caused by infection with Echinococcus granulosus, is one of the most widespread zoonotic helminth diseases. Modulation of host responses is an important strategy used by helminth parasites to promote infection. To better understand the mechanisms adopted by E. granulosus to escape host immune responses, we investigated the effects of excretory–secretory products (ES) and adult worm antigen (AWA) derived from adult E. granulosus on murine bone marrow-derived dendritic cells (BMDC).