Mutations that prevent or mimic persistent post-translational modifications of the histone H3 globular domain cause lethality and growth defects in Drosophila

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• 作者：Hillary K. Graves ; Pingping Wang ; Matthew Lagarde ; Zhihong Chen…
• 关键词：Histone post ; translational modifications ; Drosophila ; Imaginal discs ; Histone H3 globular domain ; Development
• 刊名：Epigenetics & Chromatin
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：9
• 期：1
• 全文大小：2,846 KB
• 刊物主题：Animal Genetics and Genomics; Human Genetics; Plant Genetics & Genomics; Cell Biology;
• 出版者：BioMed Central
• ISSN：1756-8935

文摘

Background Understanding the function of histone post-translational modifications is the key to deciphering how genomic activities are regulated. Among the least well-understood histone modifications in vivo are those that occur on the surface of the globular domain of histones, despite their causing the most profound structural alterations of the nucleosome in vitro. We utilized a Drosophila system to replace the canonical histone genes with mutated histone transgenes.