Bioactive cyclolanstane-type saponins from the stems of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao

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• 作者：Tingting Wang ; Jingya Ruan ; Xiaoxia Li ; Liping Chao…
• 关键词：Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao ; Stem ; Cyclolanstane ; type saponin ; HepG2 cells ; Triglyceride accumulation inhibitory effects
• 刊名：Journal of Natural Medicines
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：70
• 期：2
• 页码：198-206
• 全文大小：586 KB
• 参考文献：1.Li X, Qu L, Dong Y, Han L, Liu E, Fang S, Zhang Y, Wang T (2014) A review of recent research progress on the astragalus genus. Molecules 19:18850–18880CrossRef PubMed
  2.Verotta L, Guerrini M, El-Sebakhy NA, Asaad AM, Toaima SM, Abou-Sheer ME, Luo YD, Pezzuto JM (2001) Cycloartane saponins from Astragalus peregrinus as modulators of lymphocyte proliferation. Fitoterapia 72:894–905CrossRef PubMed
  3.Pistelli L, Pardossi S, Flamini G, Bertoli A, Manunta A (1997) Three cycloastragenol glucosides from Astragalus verrucosus. Phytochemistry 45:585–587CrossRef
  4.Isaev MI, Abubakirov NK (1990) Triterpene glycosides of Astragalus and their genins. XXXIV. Cycloaraloside E from Astragalus amarus. Khim Prir Soedin 26:559–561
  5.Ma Y, Tian Z, Kuang H, Yuan C, Shao C, Ohtani K, Kasai R, Tanaka O, Okada Y, Okuyama T (1997) Studies of the constituents of Astragalus membranaceus Bunge. III. Structures of triterpenoidal glycosides, huangqiyenins A and B, from the leaves. Chem Pharm Bull 45:358–361CrossRef
  6.Naubeev TKH, Uteniyazov KK, Kachala VV, Shashkov AS (2007) Cyclochivinoside B from the aerial part of Astragalus chivensis. Chem Nat Comp 43:166–169CrossRef
  7.Zhang Y, Wu C, Guo L, Chen Y, Han L, Liu E, Gao X, Wang T (2013) Triglyceride accumulation inhibitory effects of phenylpropanoid glycosides from Boschniakia rossica Fedtsch et Flerov. Fitoterapia 85:69–75CrossRef PubMed
  8.Gülcemal D, Masullo M, Bedir E, Festa M, Karayıldırım T, Alankus-Caliskan O, Piacente S (2012) Triterpene glycosides from Astragalus angustifolius. Planta Med 78:720–729CrossRef PubMed
  
• 作者单位：Tingting Wang (1)
  Jingya Ruan (2)
  Xiaoxia Li (2)
  Liping Chao (2)
  Pingping Shi (2)
  Lifeng Han (1) (2)
  Yi Zhang (1) (2)
  Tao Wang (1) (2)
  
  1. Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin, 300193, China
  2. Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshan Road, Nankai District, Tianjin, 300193, China
  
• 刊物主题：Pharmacology/Toxicology; Plant Sciences; Complementary & Alternative Medicine; Medicinal Chemistry; Pharmacy;
• 出版者：Springer Japan
• ISSN：1861-0293

文摘

Twelve cyclolanstane-type saponins including six new ones, astrolanosaponins A₁ (1), A₂ (2), B (3), C (4), D (5), and E (6) were obtained from the stem of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao, and their structures were elucidated by chemical and spectroscopic methods. Of the known ones, cycloastragenol-3-O-β-D-glucopyranoside (7), astraverrucin II (8), cycloaraloside E (9), huangqiyenin A (10), and huangqiyenin B (11) were isolated from the species first. Meanwhile, compounds 1–3, 5–9, and aleksandroside I (12) showed inhibitory effects on triglyceride accumulation in HepG2 cells.